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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Presenilin 2/PSEN2 Antibody Picoband®

SKU : BHA21006741

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Mfr.No.	PA1358, PA1358-10ug, PA1358-Biotin, PA1358-Cy3, PA1358-Dylight488, PA1358-Dylight550, PA1358-Dylight594, PA1358-FITC, PA1358-HRP, PA1358-APC, PA1358-PE, PA1358-iFluor647, PA1358-carrier-free
Alternative Names	Presenilin-2
Background	Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al. (1996) demonstrated that the expression pattes of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Presenilin 2/PSEN2 Antibody catalog # PA1358. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Presenilin-2;PS-2;3.4.23.-;AD3LP;AD5;E5-1;STM-2;Presenilin-2 NTF subunit;Presenilin-2 CTF subunit;PSEN2;AD4, PS2, PSNL2, STM2;
Tissue Specificity	Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P49810
Gene Name	PSEN2
Sequence	Belongs to the peptidase A22A family.
Subcellular Location	Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD (September 1995). "A familial Alzheimer's disease locus on chromosome 1". <br /><br />2. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006741-1	PA1358	-	100 ug	$370		Add to Cart
BHA21006741-2	PA1358-10ug	Sample	10 ug	$99		Add to Cart
BHA21006741-3	PA1358-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006741-4	PA1358-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006741-5	PA1358-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006741-6	PA1358-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006741-7	PA1358-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006741-8	PA1358-FITC	FITC	100 ug	$570		Add to Cart
BHA21006741-9	PA1358-HRP	HRP	100 ug	$570		Add to Cart
BHA21006741-10	PA1358-APC	APC	100 ug	$670		Add to Cart
BHA21006741-11	PA1358-PE	PE	100 ug	$670		Add to Cart
BHA21006741-12	PA1358-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006741-13	PA1358-carrier-free	carrier-free	100 ug	$370		Add to Cart

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