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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Presenilin 1/PS-1/PSEN1 Antibody Picoband®

SKU : BHA21003881

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Mfr.No.	A00138-3, A00138-3-10ug, A00138-3-Biotin, A00138-3-Cy3, A00138-3-Dylight488, A00138-3-Dylight550, A00138-3-Dylight594, A00138-3-FITC, A00138-3-HRP, A00138-3-APC, A00138-3-PE, A00138-3-iFluor647, A00138-3-carrier-free
Alternative Names	CD14 antigen
Background	Presenilin-1 (PS-1) is a presenilin protein that in humans is encoded by the PSEN1 gene. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either ly regulate gamma-secretase activity or themselves are protease enzymes. Several alteatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Presenilin 1/PS-1/PSEN1 Antibody Picoband® catalog # A00138-3. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:16148141). Acts vi
Host	Rabbit
Immunogen Region	E.coli-derived human Presenilin 1/PS-1/PSEN1 recombinant protein (Position: M1-K76).
Isotype	Rabbit IgG
Molecular Weight	53 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD14; Cd14;
Tissue Specificity	Detected on peritoneal macrophages (at protein level) (PubMed:8612135). Cell surface expression detected in lung alveolar macrophages, dendritic macrophages and lung macrophages (at protein level) (PubMed:19362712).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P49768
Gene Id	5663
Gene Name	PSEN1
Subcellular Location	Cell membrane

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Alzheimer's Disease Collaborative Group. The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nature Genet. 11: 219-222, 1995. 2. Arboleda-Velasquez, J. F., Lopera, F., O'Hare, M., Delgado-Tirado, S., Marino, C., Chmielewska, N., Saez-Torres, K. L., Amaani, D., Schultz, A. P., Sperling, R. A., Leyton-Cifuentes, D., Chen, K., and 32 others. Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report. Nature Med. 25: 1680-1683, 2019. 3. Ataka, S., Tomiyama, T., Takuma, H., Yamashita, T., Shimada, H., Tsutada, T., Kawabata, K., Mori, H., Miki, T. A novel presenilin-1 mutation (leu85pro) in early-onset Alzheimer disease with spastic paraparesis. Arch. Neurol. 61: 1773-1776, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003881-1	A00138-3	-	100 ug	$370		Add to Cart
BHA21003881-2	A00138-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003881-3	A00138-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003881-4	A00138-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003881-5	A00138-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003881-6	A00138-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003881-7	A00138-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003881-8	A00138-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003881-9	A00138-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003881-10	A00138-3-APC	APC	100 ug	$670		Add to Cart
BHA21003881-11	A00138-3-PE	PE	100 ug	$670		Add to Cart
BHA21003881-12	A00138-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003881-13	A00138-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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