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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PML Protein/Pml Antibody Picoband®

SKU : BHA21003372

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Mfr.No.	A00093-2, A00093-2-10ug, A00093-2-Biotin, A00093-2-Cy3, A00093-2-Dylight488, A00093-2-Dylight550, A00093-2-Dylight594, A00093-2-FITC, A00093-2-HRP, A00093-2-APC, A00093-2-PE, A00093-2-iFluor647, A00093-2-carrier-free
Alternative Names	SMAD family member 2
Background	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alteative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alteatively spliced transcript variants encoding different isoforms have been identified.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PML Protein/Pml Antibody Picoband® catalog # A00093-2. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes th
Host	Rabbit
Immunogen Region	E.coli-derived mouse Pml recombinant protein (Position: E107-A857).
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; hSMAD2; Smad2; SMAD2; MADH2; MADR2
Tissue Specificity	Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	Q60953
Gene Id	18854
Gene Name	Pml
Subcellular Location	Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Mouse<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Dyck, J. A., Maul, G. G., Miller, W. H., Jr., Chen, J. D., Kakizuka, A., Evans, R. M. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76: 333-343, 1994.<br /><br />2. Giorgi, C., Ito, K., Lin, H.-K., Santangelo, C., Wieckowski, M. R., Lebiedzinska, M., Bononi, A., Bonora, M., Duszynski, J., Beardi, R., Rizzuto, R., Tacchetti, C., Pinton, P., Pandolfi, P. P. PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science 330: 1247-1251, 2010.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003372-1	A00093-2	-	100 ug	$370		Add to Cart
BHA21003372-2	A00093-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003372-3	A00093-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003372-4	A00093-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003372-5	A00093-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003372-6	A00093-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003372-7	A00093-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003372-8	A00093-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003372-9	A00093-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003372-10	A00093-2-APC	APC	100 ug	$670		Add to Cart
BHA21003372-11	A00093-2-PE	PE	100 ug	$670		Add to Cart
BHA21003372-12	A00093-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003372-13	A00093-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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