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Home / Primary Antibodies / Monoclonal Antibodies

Anti-PLGF (Placental Growth Factor) Antibody BHA10204075

SKU : BHA10204075

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NeoBiotechnologies, Inc.

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Mfr.No.	5228-MSM2-P1ABX
Alternative Names	PGFL ; PIGF ; placental growth factor (PGF) ; Vascular endothelial growth factor related protein
Categories	Primary Antibodies
Cellular Localization	Extracellular(secreted)
Chromosome Location	14q24.3
Clonality	monoclonal
Description	The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Serum levels of PLGF in some cases are used as a potential biomarker for disease or genetic defect. Recent research indicates that PLGF levels are lower in mothers with Down syndrome fetuses. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.
Host	Mouse
Immunogen	Recombinant human PLGF protein
Isotype	IgG1 Kappa
Positive Control	HepG2 or HEK293T cells. Human placental and brain tumors.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P49763
Uniprot	252820
Gene Id	5228

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

ELISA, Func

Description

Optimal dilution for a specific application should be determined., ELISA ; Func

Dilution

ELISA	For coating, order Ab without BSA
Func	Order Ab without BSA & Azide

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SKU	Supplier No.	Size	Your price	Quantity
BHA10204075	5228-MSM2-P1ABX	100µg	$393.20		Add to Cart

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