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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Phospholamban/PLN Antibody Picoband®

SKU : BHA21003877

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Mfr.No.	A01395-1, A01395-1-10ug, A01395-1-Biotin, A01395-1-Cy3, A01395-1-Dylight488, A01395-1-Dylight550, A01395-1-Dylight594, A01395-1-FITC, A01395-1-HRP, A01395-1-APC, A01395-1-PE, A01395-1-iFluor647, A01395-1-carrier-free
Alternative Names	Allograft inflammatory factor 1
Background	Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. It is observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Phospholamban/PLN Antibody Picoband® catalog # A01395-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the p
Host	Rabbit
Immunogen Region	E.coli-derived human Phospholamban/PLN recombinant protein (Position: M1-C36).
Isotype	Rabbit IgG
Molecular Weight	23 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Allograft inflammatory factor 1;AIF-1;Ionized calcium-binding adapter molecule 1;Protein G1;AIF1;G1, IBA1;
Tissue Specificity	Detected in T-lymphocytes and peripheral blood mononuclear cells. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P26678
Gene Id	5350
Gene Name	PLN
Subcellular Location	Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Mouse, Rat ELISA, 0.1-0.5 ug/ml, -

Reference	1. Rodriguez P, Kranias EG (December 2005). "Phospholamban: a key determinant of cardiac function and dysfunction". Arch Mal Coeur Vaiss 98 (12): 123943. 2. McTiean, C. F.; Frye, C. S.; Lemster, B. H.; Kinder, E. A.; Ogletree-Hughes, M. L.; Moravec, C. S.; Feldman, A. M. : The human phospholamban gene: structure and expression. J. Molec. Cell Cardiol. 31: 679-692, 1999.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003877-1	A01395-1	-	100 ug	$370		Add to Cart
BHA21003877-2	A01395-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003877-3	A01395-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003877-4	A01395-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003877-5	A01395-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003877-6	A01395-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003877-7	A01395-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003877-8	A01395-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003877-9	A01395-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003877-10	A01395-1-APC	APC	100 ug	$670		Add to Cart
BHA21003877-11	A01395-1-PE	PE	100 ug	$670		Add to Cart
BHA21003877-12	A01395-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003877-13	A01395-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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