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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PDP1/PDP Antibody Picoband®

SKU : BHA21003876

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Mfr.No.	A05607-2, A05607-2-10ug, A05607-2-Biotin, A05607-2-Cy3, A05607-2-Dylight488, A05607-2-Dylight550, A05607-2-Dylight594, A05607-2-FITC, A05607-2-HRP, A05607-2-APC, A05607-2-PE, A05607-2-iFluor647, A05607-2-carrier-free
Alternative Names	phosphopantothenoylcysteine synthetase
Background	Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alteatively spliced transcript variants encoding different isoforms have been identified.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PDP1/PDP Antibody Picoband® catalog # A05607-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.
Host	Rabbit
Immunogen Region	E.coli-derived human PDP1/PDP recombinant protein (Position: S37-E537).
Isotype	Rabbit IgG
Molecular Weight	53-61 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Phosphopantothenate--cysteine ligase, Phosphopantothenoylcysteine synthetase, PPC synthetase, PPCS, COAB
Tissue Specificity	Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9P0J1
Gene Id	54704
Gene Name	PDP1
Subcellular Location	Cytosol.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Bedoyan, J. K., Hecht, L., Zhang, S., Tarrant, S., Bergin, A., Demirbas, D., Yang, E., Shin, H. K., Grahame, G. J., DeBrosse, S. D., Hoppel, C. L., Kerr, D. S., Berry, G. T. A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency. JIMD Rep. 48: 26-35, 2019. 2. Cameron, J. M., Maj, M., Levandovskiy, V., Baett, C. P., Blaser, S., MacKay, N., Raiman, J., Feigenbaum, A., Schulze, A., Robinson, B. H. Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype. Hum. Genet. 125: 319-326, 2009. 3. Huang, B., Gudi, R., Wu, P., Harris, R. A., Hamilton, J., Popov, K. M. Isoenzymes of pyruvate dehydrogenase phosphatase: DNA-derived amino acid sequences, expression, and regulation. J. Biol. Chem. 273: 17680-17688, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003876-1	A05607-2	-	100 ug	$370		Add to Cart
BHA21003876-2	A05607-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003876-3	A05607-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003876-4	A05607-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003876-5	A05607-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003876-6	A05607-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003876-7	A05607-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003876-8	A05607-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003876-9	A05607-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003876-10	A05607-2-APC	APC	100 ug	$670		Add to Cart
BHA21003876-11	A05607-2-PE	PE	100 ug	$670		Add to Cart
BHA21003876-12	A05607-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003876-13	A05607-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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