Anti-PD-1 IgG antibody is a purified recombinant antibody which recognizes human PD1 antigen. This antibody has been functionally tested in two co-culture assays.
assay conditions: The antibody acted as a PD-1 agonist when added to FcGR2B/TCR activator CHO cells co-cultured with PD-1/NFAT Jurkat cells, as indicated by PD-1-mediated inhibition of TCR activation (co-culture assay described in BPS Bioscience #78436). In addition, this anti-PD-1 antibody did not antagonize PD-1/PD-L1 binding since the TCR activation signal was still inhibited by PD-1/PD-L1 signaling in the presence of the antibody (co-culture assay described in BPS Bioscience #60535).
Formulation
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Host
Heavy chain (HC) and Light chain (LC) co-expressed in HEK293