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Home / Primary Antibodies / Polyclonal Antibodies

Anti-p57 Kip2/CDKN1C Antibody Picoband®

SKU : BHA21003413

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Mfr.No.	A01244-2, A01244-2-10ug, A01244-2-Biotin, A01244-2-Cy3, A01244-2-Dylight488, A01244-2-Dylight550, A01244-2-Dylight594, A01244-2-FITC, A01244-2-HRP, A01244-2-APC, A01244-2-PE, A01244-2-iFluor647, A01244-2-carrier-free
Alternative Names	cyclin dependent kinase inhibitor 1C
Background	Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. It is mapped to 11p15.4. This gene is imprinted, with preferential expression of the mateal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-p57 Kip2/CDKN1C Antibody Picoband® catalog # A01244-2. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-p
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human p57 Kip2/CDKN1C, identical to the related mouse sequence.
Isotype	Rabbit IgG
Molecular Weight	30 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2; CDKN1C; KIP2
Tissue Specificity	Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P49918
Gene Id	1028
Gene Name	CDKN1C
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat<br>

Reference	1. Algar, E., Brickell, S., Deeble, G., Amor, D., Smith, P. Analysis of CDKN1C in Beckwith Wiedemann syndrome. Hum. Mutat. 15: 497-508, 2000.<br /><br />2. Algar, E. M., Deeble, G. J., Smith, P. J. CDKN1C expression in Beckwith-Wiedemann syndrome patients with allele imbalance. J. Med. Genet. 36: 524-531, 1999.<br /><br />3. Arboleda, V. A., Lee, H., Paaik, R., Fleming, A., Banerjee, A., Ferraz-de-Souza, B., Delot, E. C., Rodriguez-Feandez, I. A., Braslavsky, D., Bergada, I., Dell'Angelica, E. C., Nelson, S. F., Martinez-Agosto, J. A., Achermann, J. C., Vilain, E. Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome. Nature Genet. 44: 788-792, 2012.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003413-1	A01244-2	-	100 ug	$370		Add to Cart
BHA21003413-2	A01244-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003413-3	A01244-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003413-4	A01244-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003413-5	A01244-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003413-6	A01244-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003413-7	A01244-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003413-8	A01244-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003413-9	A01244-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003413-10	A01244-2-APC	APC	100 ug	$670		Add to Cart
BHA21003413-11	A01244-2-PE	PE	100 ug	$670		Add to Cart
BHA21003413-12	A01244-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003413-13	A01244-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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