Anti- p21 Antibody

Mfr.No.	Y058132
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic and Nuclear
Clonality	polyclonal
Description	This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
Host	Rabbit
Immunogen	Synthetic peptide conjugated to KLH
Isotype	IgG
Quantity	100 µl
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Description	Specificity: Not yet tested in other species.
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, IHC, ELISA

Description

For research use only
Peptide ELISA titer: 1:20,000-1Ã¯Â¼?0,000
Western blot analysis: 1:200-1000
Immunohistochemistry: 1:50-200
Optimal dilutions/concentrations should be determined by the end use., WB ; IHC ; ELISA

Dilution

WB	1:200-1000
IHC	1:50-200

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10902537	Y058132	100 ul	$217.50		Add to Cart

Anti- p21 Antibody

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