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Home / Primary Antibodies / Polyclonal Antibodies

Anti-P Glycoprotein/ABCB1 Antibody Picoband®

SKU : BHA21003845

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Mfr.No.	A00049-4, A00049-4-10ug, A00049-4-Biotin, A00049-4-Cy3, A00049-4-Dylight488, A00049-4-Dylight550, A00049-4-Dylight594, A00049-4-FITC, A00049-4-HRP, A00049-4-APC, A00049-4-PE, A00049-4-iFluor647, A00049-4-carrier-free
Alternative Names	ATP-binding cassette, sub-family B (MDR/TAP), member 1
Background	P-GP, also called ABCB1 or PGY1, is a glycoprotein that in humans is encoded by the ABCB1 gene. It is mapped to 7q21.12. P-GP is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily. It is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent drug efflux pump with broad substrate specificity. P-GP is an ATP-dependent drug efflux pump forxenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the bloodbrain barrier.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-P Glycoprotein/ABCB1 Antibody Picoband® catalog # A00049-4. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human P Glycoprotein/ABCB1, which shares 78.9% amino acid (aa) sequence identity with mouse ABCB1.
Isotype	Rabbit IgG
Molecular Weight	141 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243; ABCB1; MDR1; PGY1
Tissue Specificity	Expressed in liver, kidney, small intestine and brain.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P08183
Gene Id	5243
Gene Name	ABCB1
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G (March 2009). 2. Ueda K, Clark DP, Chen CJ, Roninson IB,Gottesman MM, Pastan I (January 1987). "The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation". J. Biol. Chem.262 (2): 5058.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003845-1	A00049-4	-	100 ug	$370		Add to Cart
BHA21003845-2	A00049-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21003845-3	A00049-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003845-4	A00049-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003845-5	A00049-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003845-6	A00049-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003845-7	A00049-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003845-8	A00049-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21003845-9	A00049-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21003845-10	A00049-4-APC	APC	100 ug	$670		Add to Cart
BHA21003845-11	A00049-4-PE	PE	100 ug	$670		Add to Cart
BHA21003845-12	A00049-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003845-13	A00049-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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