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Home / Antibodies

Anti-NRF1 Antibody

SKU : BHA10923805

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y050179
Categories	Primary Antibodies
Clonality	polyclonal
Description	NRF1 (also known as nuclearrespiratory factor 1, alpha palindromic binding protein andalpha-pal) is the mammalian homolog to the erect wing(ewg) Drosophila protein that is required for properdevelopment of the central nervous system and indirectflight muscles. In mammals NRF1 functions as atranscription factor that activates the expression of theEIF2S1 (EIF2-alpha) gene. This protein links thetranscriptional modulation of key metabolic genes tocellular growth and development and has been implicatedin the control of nuclear genes required for respiration,heme biosynthesis, and mitochondrial DNA transcriptionand replication. NRF1 forms a homodimer and binds DNAas a dimer. NRF1 shows a nuclear localization and iswidely expressed in embryonic, fetal, and adult tissues.Phosphorylation of NRF1 enhances DNA binding. Multiplesplice variants have been identified for this protein.
Formulation	Liquid
Host	Rabbit(Rb)
Guarantee	abm guarantees that all our Anti-NRF1 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Immunogen	This protein A purified antibody was preparedfrom whole rabbit serum produced by repeated immunizationswith a purified recombinant mouse NRF1 proteincorresponding to aa 1- 534 of the native protein.
Isotype	IgG
Quantity	100 μg
Recommended Dilution	This protein A purified antibody has beentested for use in ELISA, immunohistochemistry and by westernblot. Specific conditions for reactivity should be optimized by theend user. Expect a band approximately 67 kDa in sizecorresponding to NRF1 by western blotting in the appropriate celllysate or extract. Splice variants exist for this protein that mayresult in the detection of lower molecular weight bands.
Shipping Condition	Ice Packs
Species Reactivity	Avain ; Human ; Mouse ; Rat
Specificity	This protein A purified antibody is directed against mouse NRF1. The product was purified frommonospecific antiserum by protein A affinity purification. BLAST analysis was used to suggest reactivity with this protein frommouse, human, chimpanzee, dog, rat, chicken, frog and zebrafish based on very high sequence homology with theimmunogen sequence. Cross reactivity with NRF1 homologues from other sources has not been determined.

Gene Name	NRF1
Clone No	Polyclonal

Concentration	1µg/ul
Purity	Protein A Purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Storage Condition	-20C

Description	ELISA ; WB

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SKU	Supplier No.	Size	Your price	Quantity
BHA10923805	Y050179	100 ug	$1162.50		Add to Cart

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