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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NOX5 Antibody Picoband®

SKU : BHA21002848

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Mfr.No.	A03119, A03119-10ug, A03119-Biotin, A03119-Cy3, A03119-Dylight488, A03119-Dylight550, A03119-Dylight594, A03119-FITC, A03119-HRP, A03119-APC, A03119-PE, A03119-iFluor647, A03119-carrier-free
Alternative Names	ribonuclease A family member 3
Background	NOX5 (Nadph Oxidase 5), also known as NOX5A or NOX5B, is a protein which in humans is encoded by the NOX5 gene. The Inteational Radiation Hybrid Mapping Consortium mapped the NOX5 gene to chromosome 15. NOX5 is a novel NADPH oxidase that generates superoxide and functions as an H+ channel in a Ca2+-dependent manner. It is found that, when heterologously expressed, NOX5 was quiescent in unstimulated cells. However, in response to elevations of the cytosolic Ca2+ concentration, it generated large amounts of superoxide. Using RT-PCR and Southe and Weste blot analyses, NOX5 was identified as a flavin-containing Ca2+-dependent oxidase present in hairy leukemic cells (HC), but not normal B cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-NOX5 Antibody Picoband® catalog # A03119. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positi
Host	Rabbit
Immunogen Region	E.coli-derived human NOX5 recombinant protein (Position: A21-F765).
Isotype	Rabbit IgG
Molecular Weight	86 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Eosinophil cationic protein; ECP; Ribonuclease 3; RNase 3; RNASE3; ECP; RNS3
Tissue Specificity	Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q96PH1
Gene Id	79400
Gene Name	NOX5
Subcellular Location	Secreted. Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Banfi, B., Molnar, G., Maturana, A., Steger, K., Hegedus, B., Demaurex, N., Krause, K.-H. A Ca2+-activated NADPH oxidase in testis, spleen, and lymph nodes. J. Biol. Chem. 276: 37594-37601, 2001.<br /><br />2. Kamiguti, A. S., Serrander, L., Lin, K., Harris, R. J., Cawley, J. C., Allsup, D. J., Slupsky, J. R., Krause, K.-H., Zuzel, M. Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J. Immun. 175: 8424-8430, 2005.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002848-1	A03119	-	100 ug	$370		Add to Cart
BHA21002848-2	A03119-10ug	Sample	10 ug	$99		Add to Cart
BHA21002848-3	A03119-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002848-4	A03119-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002848-5	A03119-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002848-6	A03119-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002848-7	A03119-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002848-8	A03119-FITC	FITC	100 ug	$570		Add to Cart
BHA21002848-9	A03119-HRP	HRP	100 ug	$570		Add to Cart
BHA21002848-10	A03119-APC	APC	100 ug	$670		Add to Cart
BHA21002848-11	A03119-PE	PE	100 ug	$670		Add to Cart
BHA21002848-12	A03119-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002848-13	A03119-carrier-free	carrier-free	100 ug	$370		Add to Cart

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