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Home / Primary Antibodies

Anti-Nogo Receptor (Nogo-R, Reticulon receptor 4, NgR1, Nogo-66 Receptor) Antibody

SKU : BHA10920506

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y051708
Categories	Primary Antibodies
Clonality	polyclonal
Description	The Nogo receptor is a leucine-rich repeat (LRR) containing protein with a glycosylphosphatidylinositol (GPI) anchored C-terminus. The receptor was identified on the basis of its ability to bind with high affinity to Nogo-A a member of the reticulon family expressed in the cell membrane of oligodendrocytes.1Nogo-A attracted attention when it was demonstrated that it is a myelin protein capable of inhibiting axonal growth following nerve injury.2,3 Other myelin proteins also identified as axonal growth inhibitors are the myelin-associated glycoprotein (MAG) a sialic-dependent immunoglobulin-like family member lectin (SIGLEC) and the oligodendrocyte myelin glycoprotein (OmgP) which is a GPI-anchored membrane protein. Remarkably, despite their structural diversity, all three axonal growth inhibitors bind to the Nogo receptor with high affinity.4,5Since the Nogo receptor is a GPI-anchored protein it was expected that it would require another protein component to transduce the Nogo-A binding information into the responding neurons interior. Indeed, it was shown that the neurotrophin receptor p75 (p75NTR) interacts with Nogo receptor and a third protein termed LINGO-1 to mediate axonal growth inhibition signaling.6,7We are pleased to offer a new antibody directed against a highly conserved epitope situated in the linker region between the LRRs and the GPI anchor. The antibody will work with human, mouse and rat samples and has been tested in Western blot, immunocytochemistry and immunohistochemistry techniques.
Formulation	Liquid
Host	Rabbit(Rb)
Guarantee	abm guarantees that all our Anti-Nogo Receptor (Nogo-R, Reticulon receptor 4, NgR1, Nogo-66 Receptor) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Immunogen	Peptide (C)GDSPPGNGSGPRHIND corresponding to amino acid residues 366-381 of the human Nogo receptor (Accession Q9BZR6).
Isotype	IgG
Quantity	50μl
Recommended Dilution	For research purposes only, not for human use.
Shipping Condition	Ice Packs
Species Reactivity	Mouse ; Rat

Gene Name	NOGO-R
Clone No	Polyclonal

Concentration	1µg/ul
Purity	Affinity purified on immobilized antigen.
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Storage Condition	-20C

Description	ICC ; IHC ; IF ; WB

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SKU	Supplier No.	Size	Your price	Quantity
BHA10920506	Y051708	50 ul	$1335		Add to Cart

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