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Home / Antibodies

Anti-NGFR p75 Antibody

BHA10916535
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Contact us to order
Tel
+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
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Buffer PBS, pH 7.4 with 0.02% Sodium Azide
Concentration 100µg/100ul
Description Specificity: NGFR p75 antibody detects endogenous levels of NGFR p75 protein. Not tested with other proteins
Relevance: Nerve Growth Factor Receptor, also termed NGFR p75, p75NTR, or CD271 is the low affinity NGFR (LNGFR) which binds NGF and other neurotrophins including BDNF, NT3, NT4/5 with similar, low affinity. NGFR p75 is a 75kD transmembrane glycoprotein (399 a.a.) consisting of an extracellular domain (222 a.a.) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 a.a.), and a cytoplasmic domain (155 a.a.). NGFR p75 is mainly expressed in Schwann cells and neurons and in a variety of non neuronal cells. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system. The signal transduction mechanisms and components leading to NGFR p75 multiple signals are complex and not well understood. In contrast to other members of the neurotrophin receptors family (TrkA, TrkB and TrkC tyrosine kinases), NGFR p75 lacks intrinsic catalytic activity. It has been suggested that NGFR p75 interacts with TrkA to form high affinity binding sites and to modulate TrkA signaling. NGFR p75 belongs to the TNF receptor superfamily which includes TNFR, CD40 and Fas. These receptors all have an intracellular death domain and can couple to parallel signaling pathways leading to apoptotic cell death or activation of the transcription factor NF kappaB. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).
Format Liquid
Purity Protein A purified
Storage This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition -20C
Applications WB, ELISA
Description Recommended dilutions Peptide ELISA: 1:80,000 WB: 1/500 - 1/1000 Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user, WB ; ELISA
Dilution

ELISA1:80,000
WB1:500-1:1000
SKU Supplier No. Size Your price Quantity
BHA10916535 Y058095 100 ul $217.50
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