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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Neurokinin 1 Receptor (NK1R) (extracellular)-FITC Antibody

SKU : BHA21301313

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Alomone Labs

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Mfr.No.	ATR-001-F, ATR-001-F_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	Substance P (SP), Neurokinin A (NKA) and Neurokinin B (NKB) are all peptides belonging to the Tachykinin protein family. These three peptides which demonstrate a quite heterogeneity in their distribution exert their effect via three receptors: Neurokinin 1-3 receptors, members of the G-protein coupled receptor superfamily. However, Neurokinin 1 Receptor (NK1) preferentially binds Substance P, Neurokinin 2 Receptor (NK2) to NKA and Neurokinin 3 Receptor (NK3) to NKB1.Neurokinin receptors are distinguished by their seven transmembrane domains, an extracellular N-terminus and a cytosolic C-terminal. An unusual property of these receptors is the presence of introns as part of their structural organization1-3. Tachykinin receptors undergo alternative splicing. For example, NK1 is detected with different C-terminal lengths. The longer receptor isoform is found in the brain whereas the truncated form is mostly detected in the periphery1,4.Due to the broad expression profile of tachykinin peptides, their respective receptors are also expressed in a similar fashion. NK1 is widely expressed in neurons endothelial cells, muscle and immune system cells. NK2 is broadly expressed in the periphery and its expression in the brain is quite restricted. NK3 on the other hand is largely expressed in the central nervous system and is also detected in the uterus, skeletal muscle, lung and liver1.Neurokinin receptors have been found in many pathophysiological indications and have therefore become targets for the development of pharmacological compounds. Such indications include cancer, psychological disorders, migraine and various inflammations, just to name a few5-8.
Clonality	Polyclonal
Description	Anti-Neurokinin 1 Receptor (NK1R) (extracellular) Antibody (#ATR-001) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect live cell flow cytometry, and live cell imaging applications. It has been designed to recognize NK1 from rat, mouse, and human samples. Anti-Neurokinin 1 Receptor (NK1R) (extracellular)-FITC Antibody (#ATR-001-F) is directly conjugated to fluorescein isothiocyanate (FITC). The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.
Formulation	PBS pH7.4, 1% BSA with 0.05% sodium azide
Host	Rabbit
Immunogen Region	2nd extracellular loop
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	50 ul double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	NK1 receptor, Tachykinin receptor 1, TACR1, Substance-P receptor, SPR
UNSPSC Code	41116161
Note	Homology: Mouse - identical; human - 13/15 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: RIC-001-F Specifictiy: TACR1 Is Toxin: No Standard quality control of each lot: Western blot analysis (unlabeled antibody, #ATR-001), and direct flow cytometry (labeled antibody). Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P14600
Gene Id	24807
Target	NK1 receptor, Tachykinin receptor 1, TACR1, Substance-P receptor, SPR
Sequence	CMIEWPEHPNRTYEK, corresponding to amino acid residues 180-194 of rat NK1 receptor

Conjugates	Fluorescein isothiocyanate (FITC).

Concentration	1 mg/ml
Form	Lyophilized powder
Preservative	1% BSA, 0.05% NaN3
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	FC, LCI
Dilution	Contact Alomone for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21301313-1	ATR-001-F_50 mcl	50 mcl	$797		Add to Cart
BHA21301313-2	ATR-001-F_50 mcl	2x50 mcl	$1397		Add to Cart
BHA21301313-3	ATR-001-F_50 mcl	5x50 mcl	$2743		Add to Cart
BHA21301313-4	ATR-001-F_50 mcl	10x50 mcl	$3764		Add to Cart

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