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Home / Antibodies

Anti-N-Myc Antibody

BHA10915789
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Contact us to order
Tel
+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
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Buffer PBS, pH 7.4 with 0.02% Sodium Azide
Concentration 100µg/100ul
Description Specificity: N-Myc antibody detects endogenous levels of N-Myc protein. Not tested with other proteins
Relevance: The v-myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans the family consists of five genes: c-myc, N-myc, R-myc, L-myc and B-myc. Amplification of the N-myc gene has been found in human neuroblastomas and cell lines. The extent of N-myc amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-myc gene gives rise to at least two nuclear phosphoproteins of 64 kDa and 67 kDa that exhibit relatively short (30 minute) half lives in vivo and exhibit DNA binding properties in vitro. Members of the Myc gene family code for proteins that homodimerize but do not bind well to DNA. Myc-Max heterodimers, however, bind with great affinity to the sequence CACGTG and act to initiate transcription of target genes
Format Liquid
Purity Purified
Storage This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition -20C
Applications WB, ELISA
Description Recommended dilutions Peptide ELISA: 1:80,000 WB: 1/500 - 1/1000 Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user, WB ; ELISA
Dilution

ELISA1:80,000
WB1:500-1:1000
SKU Supplier No. Size Your price Quantity
BHA10915789 Y058042 100 ul $217.50
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