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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MUC1 Antibody

SKU : BHA21000041

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Mfr.No.	PB9145, PB9145-10ug, PB9145-Biotin, PB9145-Cy3, PB9145-Dylight488, PB9145-Dylight550, PB9145-Dylight594, PB9145-FITC, PB9145-HRP, PB9145-APC, PB9145-PE, PB9145-iFluor647, PB9145-carrier-free
Alternative Names	Mucin 1, cell surface associated
Background	Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. It is mapped to 1q22. Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells. Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This gene also can suppress pulmonary innate immunity, and its antiinflammatory activity may play an important modulatory role during microbial infection.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MUC1 Antibody Picoband® catalog # PB9145. Tested in IHC applications. This antibody reacts with Human.
Function	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer.
Host	Rabbit
Immunogen Region	E.coli-derived human MUC1 recombinant protein (Position: R945-G1097). Human MUC1 shares 56% amino acid (aa) sequence identity with mouse MUC1.
Isotype	Rabbit IgG
Molecular Weight	47 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	ADMCKD antibody;ADMCKD1 antibody;Breast carcinoma associated antigen DF3 antibody;Breast carcinoma-associated antigen DF3 antibody;CA 15-3 antibody;CA15 3 antibody;CA15 3 antigen antibody;CA15.3 antibody;Cancer antigen 15-3 antibody;Carcinoma associated mucin antibody;Carcinoma-associated mucin antibody;CD 227 antibody;CD227 antibody;DF3 antigen antibody;EMA antibody;Episialin antibody;H23 antigen antibody;H23AG antibody;KL 6 antibody;KL-6 antibody;KL6 antibody;Krebs von den Lungen-6 antibody;MAM 6 antibody;MAM6 antibody;MCD antibody;MCKD antibody;MCKD1 antibody;Medullary cystic kidney disease 1 (autosomal dominant) antibody;MUC 1 antibody;MUC-1 antibody;MUC-1/SEC antibody;MUC-1/X antibody;MUC1 antibody;MUC1-alpha antibody;MUC1-beta antibody;MUC1-CT antibody;MUC1-NT antibody;MUC1/ZD antibody;MUC1_HUMAN antibody;Mucin 1 antibody;Mucin 1 transmembrane antibody;Mucin 1, cell surface associated antibody;Mucin-1 subunit beta antibody;Peanut reactive urinary mucin antibody;Peanut-reactive urinary mucin antibody;PEM antibody;PEMT antibody;Polymorphic epithelial mucin antibody;PUM antibody;Tumor associated epithelial membrane antigen antibody;Tumor associated epithelial mucin antibody;Tumor associated mucin antibody;Tumor-associated epithelial membrane antigen antibody;Tumor-associated mucin antibody
Tissue Specificity	Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P15941
Gene Id	4582
Gene Name	MUC1
Subcellular Location	Apical cell membrane ; Single- pass type I membrane protein . Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, intealized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat

Reference	1. Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani EN, Wilson D (September 1990). "Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin". J. Biol. Chem. 265 (25): 1528693. 2. Wei, X., Xu, H., Kufe, D. MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. Molec. Cell 21: 295-305, 2006. 3. Lu, W., Hisatsune, A., Koga, T., Kato, K., Kuwahara, I., Lillehoj, E. P., Chen, W., Cross, A. S., Gendler, S. J., Gewirtz, A. T., Kim, K. C. Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J. Immun. 176: 3890-3894, 2006.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000041-1	PB9145	100 ug	-	$370		Add to Cart
BHA21000041-3	PB9145-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000041-4	PB9145-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000041-5	PB9145-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000041-6	PB9145-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000041-7	PB9145-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000041-8	PB9145-FITC	100 ug	FITC	$570		Add to Cart
BHA21000041-9	PB9145-HRP	100 ug	HRP	$570		Add to Cart
BHA21000041-10	PB9145-APC	100 ug	APC	$670		Add to Cart
BHA21000041-11	PB9145-PE	100 ug	PE	$670		Add to Cart
BHA21000041-12	PB9145-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000041-13	PB9145-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000041-2	PB9145-10ug	10 ug	Sample	$99		Add to Cart

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