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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MTA2/PID Picoband® Antibody

SKU : BHA21002549

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Mfr.No.	A03073-1, A03073-1-10ug, A03073-1-Biotin, A03073-1-Cy3, A03073-1-Dylight488, A03073-1-Dylight550, A03073-1-Dylight594, A03073-1-FITC, A03073-1-HRP, A03073-1-APC, A03073-1-PE, A03073-1-iFluor647, A03073-1-carrier-free
Alternative Names	metastasis associated 1 family member 2
Background	Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene. It is mapped to 11q12.3. This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression patte and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either ly or inly in transcriptional regulation. Their in effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MTA2/PID Picoband® Antibody catalog # A03073-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
Host	Rabbit
Immunogen Region	E.coli-derived human MTA2/PID recombinant protein (Position: M1-D668).
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Metastasis-associated protein MTA2; Metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex; MTA2; MTA1L1; PID
Tissue Specificity	Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	O94776
Gene Id	9219
Gene Name	MTA2
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Cui, Q., Matsusue, K., Toh, Y., Kono, A., Takiguchi, S. Assignment of the metastasis-associated gene (Mta1) to mouse chromosome band 12F and the metastasis-associated gene 2 (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization. Cytogenet. Cell Genet. 94: 246-247, 2001.<br /><br />2. Futamura, M., Nishimori, H., Shiratsuchi, T., Saji, S., Nakamura, Y., Tokino, T. Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1. J. Hum. Genet. 44: 52-56, 1999.<br /><br />3. Luo, J., Su, F., Chen, D., Shiloh, A., Gu, W. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408: 377-381, 2000.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002549-1	A03073-1	-	100 ug	$370		Add to Cart
BHA21002549-2	A03073-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002549-3	A03073-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002549-4	A03073-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002549-5	A03073-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002549-6	A03073-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002549-7	A03073-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002549-8	A03073-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002549-9	A03073-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002549-10	A03073-1-APC	APC	100 ug	$670		Add to Cart
BHA21002549-11	A03073-1-PE	PE	100 ug	$670		Add to Cart
BHA21002549-12	A03073-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002549-13	A03073-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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