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Home / Primary Antibodies

Anti-MSH2 Antibody

SKU : BHA10903422

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y050845
Categories	Primary Antibodies
Clonality	monoclonal
Description	MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.
Host	Mouse
Immunogen	Ni-NTA purified recombinant human MSH2 expressed in E. Coli strain BL21 (DE3).
Isotype	IgG1
Quantity	100 µg
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Concentration	1µg/ul
Format	Liquid
Purity	purified by protein G affinity chromatography
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications	WB, IHC, ELISA
Description	WB ; IHC ; ELISA

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10903422	Y050845	100 ug	$675		Add to Cart

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