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Home / Primary Antibodies

Anti-Mouse CD106/VCAM-1-Biotin Conjugate Antibody

SKU : BHA10916098

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y053647
Categories	Primary Antibodies
Clonality	monoclonal
Description	VCAM-1 is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (i.e., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein. The M/K-2 monoclonal antibody immunoprecipitates a peptide that gives a single band on SDS-PAGE gels with an apparent Mr of ~100 kDa under reducing conditions and 92 kDa under nonreducing conditions.
Host	Rat
Isotype	IgG1 Kappa
Quantity	100 µg
Reactivity	Mouse
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Concentration	100µg/200ul
Description	Specificity: CD106/VCAM-1 (~Mr 100-kDa)
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications	FACS
Description	Identification and enumeration of CD106 cells by flow cytometry Identification of VCAM-1+ cells by immunofluorescence and immunohistochemical staining, FACS

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SKU	Supplier No.	Size	Your price	Quantity
BHA10916098	Y053647	100 ug	$607.50		Add to Cart

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