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Home / Primary Antibodies / Monoclonal Antibodies

Anti-MiTF

SKU : BHA15100207

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Mfr.No.	AM554-5M
Clonality	Monoclonal
Description	Micropthalmia-associated Transcription Factor (MitF) is a basic helix-loop-helix leucine zipper transcription factor involved in melanocyte and osteoclast development. MiTF exists in two isoforms differing by 66 amino acids at the NH2 terminus. Melanocytes express the shorter forms of MitF with molecular weight of 52 kDa-56 kDa, while osteoclasts, mast cells and heart cells, B16 melanoma, optic cup-derived retinal pigment epithelium cells express the longer Mi form of about 60-70kDa that plays a critical role in their differentiation. MiTF Mutations leads to auditory pigmentary syndromes, such as Waardenburg Syndrome Type II, Type IIa and Tietz Syndrome in humans. This antibody identifies serine phosphorylated and non-phosphorylated melanocytic isoforms of micropthalmia. It is useful in identifying Malignant Melanoma , and distinguishing mast cell lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epitheloid cell differentiation) express MiTF in a high percentage of cases ~90%)
Host	Mouse
Isotype	IgG1/K
Reactivity	Human
Species	Mouse

Clone No	MiTF/A13
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:10-20

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AM554-5M	AM554-5M	6 mL	$191		Add to Cart
AM554-10M	AM554-10M	100 tests - i6000	$332		Add to Cart
AX554-50D	AX554-50D	50 tests - Xmatrx	$196		Add to Cart
AX554-YCD	AX554-YCD	160 tests - Xmatrx	$560		Add to Cart
MU554-UC	MU554-UC	1ml Conc	$336		Add to Cart
MU554-5UC	MU554-5UC	0.5ml Conc	$237		Add to Cart

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