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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MEK1/MAP2K1 Antibody Picoband®

SKU : BHA21006755

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Mfr.No.	PA1376, PA1376-10ug, PA1376-Biotin, PA1376-Cy3, PA1376-Dylight488, PA1376-Dylight550, PA1376-Dylight594, PA1376-FITC, PA1376-HRP, PA1376-APC, PA1376-PE, PA1376-iFluor647, PA1376-carrier-free
Alternative Names	Dual specificity mitogen-activated protein kinase kinase 1
Background	Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Rampoldi et al. (1997) localized the MAP2K1 gene to 15q22.1-q22.33.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MEK1/MAP2K1 Antibody catalog # PA1376. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this init
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human MEK1, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Dual specificity mitogen-activated protein kinase kinase 1;MAP kinase kinase 1;MAPKK 1;MKK1;2.7.12.2;ERK activator kinase 1;MAPK/ERK kinase 1;MEK 1;MAP2K1;MEK1, PRKMK1;
Tissue Specificity	Widely expressed, with extremely low levels in brain. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q02750
Gene Name	MAP2K1
Sequence	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Nucleus. Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Immunocytochemistry , 0.5-1ug/ml, Human, -<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet Cell Genet 78 (3-4): 3013.<br /><br />2. Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem 268 (15): 114359.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006755-1	PA1376	-	100 ug	$370		Add to Cart
BHA21006755-2	PA1376-10ug	Sample	10 ug	$99		Add to Cart
BHA21006755-3	PA1376-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006755-4	PA1376-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006755-5	PA1376-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006755-6	PA1376-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006755-7	PA1376-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006755-8	PA1376-FITC	FITC	100 ug	$570		Add to Cart
BHA21006755-9	PA1376-HRP	HRP	100 ug	$570		Add to Cart
BHA21006755-10	PA1376-APC	APC	100 ug	$670		Add to Cart
BHA21006755-11	PA1376-PE	PE	100 ug	$670		Add to Cart
BHA21006755-12	PA1376-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006755-13	PA1376-carrier-free	carrier-free	100 ug	$370		Add to Cart

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