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Home / Primary Antibodies / Monoclonal Antibodies

Anti-MCM2

SKU : BHA15100305

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BioGenex Laboratories

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Mfr.No.	AN834-5M
Clonality	Monoclonal
Description	Minichromosome maintenance protein 2 (MCM2) is known as DNA replication licensing factor. MCM2, is a member of the MCM family that regulates mammalian DNA replication. This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryoes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. MCM2 acts as a factor to license DNA for one and only one round of replication per cell cycle. In the cell cycle, levels of the MCM family gradually increase in a variable manner from G0 into the G1/S phase. In the G0 stage, the amounts of MCM2 and MCM5 proteins are much lower than that of MCM7 and MCM3 proteins, so some of them participate in cell cycle regulation. MCM2 is localized in the nucleus throughout interphase. It is required for entry into the S phase and cell division. Anti-MCM2 labels proliferating cells in normal and tumor tissue. MCM2 has been used as a proliferation marker superior to Ki-67 for identification of premalignant lesions in colon, lung and other epithelial tissues. In addition, the MCM2 antibody is helpful in the distinction of malignant mesothelioma (higher labeling index) from reactive mesothelial proliferation
Host	Rabbit
Isotype	IgG
Reactivity	Human
Species	Rabbit

Clone No	EP40
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:30-50

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AN834-5M	AN834-5M	6 mL	$353		Add to Cart
AN834-10M	AN834-10M	100 tests - i6000	$625		Add to Cart
AY834-50D	AY834-50D	50 tests - Xmatrx	$370		Add to Cart
AY834-YCD	AY834-YCD	160 tests - Xmatrx	$999		Add to Cart
NU834-UC	NU834-UC	1ml Conc	$489		Add to Cart
NU834-5UC	NU834-5UC	0.5ml Conc	$339		Add to Cart

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