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Home / Primary Antibodies

Anti-MASH1 Antibody

BHA10917590
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Contact us to order
Tel
+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
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Buffer PBS, pH 7.4 with 0.02% sodium azide.
Concentration 100µg/100ul
Description Specificity: This Polyclonal antibody is directed against human MASH1 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human MASH1. Cross-reactivity with MASH1 from other sources has not been determined.
Relevance: Mash1, alternatively titled Hash1 or ACSL1, is a member of the basic helix-loop-helix (BHLH) family of transcription factors. Achaete-scute homolog 1 may play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. It is essential for the generation of olfactory and autonomic neurons and activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation. Between embryonic days 8.5 and 10.5 it is found in the neuroepithelium of the midbrain and ventral forebrain, as well as in the spinal cord. Between days 10.5 and 12.5 its expression pattern changes from a restricted to a widespread one, it is then found at variable levels in the ventricular zone in all regions of the brain. From day 12.5 to post-natal stages it is also expressed in cells outside of the ventricular zone through the brain, and in addition it is also expressed during development of the olfactory epithelium and neural retina.
Format Liquid
Purity Affinity purified
Storage This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition -20C
Applications WB
Description Recommended dilutions
WB: 1/500~3000
Predicted molecular weight: 25 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user., WB
Dilution

WB1:500~3000
SKU Supplier No. Size Your price Quantity
BHA10917590 Y080072 100 ul $187.50
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