Mad1 negatively regulates mitosis by preventing cells with misaligned chromosomes from dividing. It is an important target in cancer research because it may sensitize cells to existing chemotherapeutics and its expression may be an indicator of cellular sensitivity to chemotherapy. Mad 1is known to repress Myc target genes and antagonize Myc function.
Host
Mouse
Immunogen
Recombinant human Mad1
Isotype
IgG2b
Quantity
100 µg
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Shipping Condition
Ice Packs
Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Concentration
100µg/100ul
Description
Specificity: Reacts with human Mad1; other species specificity has not yet been determined
Format
Liquid
Purity
Purified ascites.
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition
-20C
Applications
WB, IP, IF
Description
Titrate for optimal dilution for your application., WB ; IP ; IF