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Home / Primary Antibodies / Polyclonal Antibodies

Anti-LONP1/Lon Antibody Picoband®

SKU : BHA21002233

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Mfr.No.	A03808-2, A03808-2-10ug, A03808-2-Biotin, A03808-2-Cy3, A03808-2-Dylight488, A03808-2-Dylight550, A03808-2-Dylight594, A03808-2-FITC, A03808-2-HRP, A03808-2-APC, A03808-2-PE, A03808-2-iFluor647, A03808-2-carrier-free
Alternative Names	lon peptidase 1, mitochondrial
Background	Lon protease homolog, mitochondrial is an enzyme that in humans is encoded by the LONP1 gene. It is mapped to 19p13.3. This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-LONP1/Lon Antibody Picoband® catalog # A03808-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the a
Host	Rabbit
Immunogen Region	E.coli-derived human LONP1/Lon recombinant protein (Position: R137-A320).
Isotype	Rabbit IgG
Molecular Weight	106 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Lon protease homolog, mitochondrial; LONHs; Lon protease-like protein; LONP; Mitochondrial ATP-dependent protease Lon; Serine protease 15; LONP1; PRSS15
Tissue Specificity	Duodenum, heart, lung and liver, but not thymus.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P36776
Gene Id	9361
Gene Name	LONP1
Subcellular Location	Mitochondrion matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Petukhova GV, Grigorenko VG, Lykov IP, Yarovoi SV, Lipkin VM, Gorbalenya AE (February 1994). "Cloning and sequence analysis of cDNA for a human homolog of eubacterial ATP-dependent Lon proteases". FEBS Letters. 340 (12): 258.<br /><br />2. Pinti M, Gibellini L, Liu Y, Xu S, Lu B, Cossarizza A (December 2015). "Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer". Cellular and Molecular Life Sciences. 72 (24): 480724.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002233-1	A03808-2	-	100 ug	$370		Add to Cart
BHA21002233-2	A03808-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002233-3	A03808-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002233-4	A03808-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002233-5	A03808-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002233-6	A03808-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002233-7	A03808-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002233-8	A03808-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002233-9	A03808-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002233-10	A03808-2-APC	APC	100 ug	$670		Add to Cart
BHA21002233-11	A03808-2-PE	PE	100 ug	$670		Add to Cart
BHA21002233-12	A03808-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002233-13	A03808-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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