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Home / Primary Antibodies / Monoclonal Antibodies

Anti-liver Arginase/ARG1 Antibody Picoband® (monoclonal, 2B12)

SKU : BHA21002720

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Mfr.No.	M01106-4, M01106-4-10ug, M01106-4-Biotin, M01106-4-Cy3, M01106-4-Dylight488, M01106-4-Dylight550, M01106-4-Dylight594, M01106-4-FITC, M01106-4-HRP, M01106-4-APC, M01106-4-PE, M01106-4-iFluor647, M01106-4-carrier-free
Alternative Names	additional sex combs like 1,transcriptional regulator
Background	ARG1 (arginase, live) is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. The isoform encoded byARG1, referred to as the liver, or A-I, isoform, contributes 98% of the arginase activity in liver but is also present in red cells. Using a rat liverARG1cDNA clone to probe a human liver cDNA library,Haraguchi et al. (1987)isolated and characterized a cDNA corresponding to theARG1gene.The ARG1 gene is mapped on 6q23.2 and the arginase gene contains 8 exons. By immunologic studies, 90% of the arginase in red blood cell and liver was precipitated by the antibody, whereas only 50% of the arginase in kidney, brain, and the gastrointestinal tract reacted with it. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-liver Arginase/ARG1 Antibody Picoband® (monoclonal, 2B12) catalog # M01106-4. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors,such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG).Acts as coactivator of RARA
Host	Mouse
Immunogen Region	E.coli-derived human liver Arginase/ARG1 recombinant protein (Position: E25-D183).
Isotype	Mouse IgG2b
Molecular Weight	35 kDa
Reactivity	Human, Mouse, Rat, Monkey
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Putative Polycomb group protein ASXL1; Additional sex combs-like protein 1; ASXL1; KIAA0978
Tissue Specificity	Widely expressed at low level. Expressed in heart,brain,skeletal muscle,placenta,pancreas,spleen,prostate,mall intestine,colon,peripheral blood,leukocytes,bone marrow and fetal liver.Highly expressed in testes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P05089
Gene Id	383
Gene Name	ARG1
Clone No	Clone: 2B12
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml, Monkey, Mouse, Rat<br>Flow Cytometry (Fixed), 1-3u/1x10<sup>6</sup> cells, Human

Reference	1. Cardoso, M. L., Martins, E., Vasconcelos, R., Vilarinho, L., Rocha, J. Identification of a novel R21X mutation in the liver-type arginase gene (ARG1) in four Portuguese patients with argininemia. Hum. Mutat. 14: 355-356, 1999.<br /><br />2. Grody, W. W., Dodson, A., Klein, D., Ke, R. M., Bassand, P., Cederbaum, S. D. Molecular genetic study of human arginase deficiency. (Abstract) Am. J. Hum. Genet. 45 (suppl.): A191 only, 1989.<br /><br />3. Haraguchi, Y., Takiguchi, M., Amaya, Y., Kawamoto, S., Matsuda, I., Mori, M. Molecular cloning and nucleotide sequence of cDNA for human liver arginase. Proc. Nat. Acad. Sci. 84: 412-415, 1987.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002720-1	M01106-4	-	100 ug	$370		Add to Cart
BHA21002720-2	M01106-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21002720-3	M01106-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002720-4	M01106-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002720-5	M01106-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002720-6	M01106-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002720-7	M01106-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002720-8	M01106-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21002720-9	M01106-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21002720-10	M01106-4-APC	APC	100 ug	$670		Add to Cart
BHA21002720-11	M01106-4-PE	PE	100 ug	$670		Add to Cart
BHA21002720-12	M01106-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002720-13	M01106-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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