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Home / Primary Antibodies

Anti-LIMK2 (Phospho-Thr505) Antibody

SKU : BHA10916780

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y011127
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Host	Rabbit
Immunogen	The antiserum was produced against synthesized phosphopeptide derived from human LIMK2 around the phosphorylation site of threonine 505 (R-Y-TP-V-V).
Quantity	100 µg
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	1µg/ul
Description	Specificity: LIMK2 (phospho-Thr505) antibody detects endogenous levels of LIMK2 only when phosphorylated at threonine 505.
Format	Liquid
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, IHC

Description

WB: 1:500~1000 IHC: 1:50~1:100, WB ; IHC

Dilution

WB	1:500~1000
IHC	1:50-1:100~

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SKU	Supplier No.	Size	Your price	Quantity
BHA10916780	Y011127	100 ug	$427.50		Add to Cart

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