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Home / Primary Antibodies / Monoclonal Antibodies

Anti-LAG3 Antibody

SKU : BHA14800042

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GenomeMe Lab Inc

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Mfr.No.	IHC103-7
Clonality	Monoclonal
Description	LAG3 (Lymphocyte-activation gene 3) was discovered in 1990 and was previously designated as CD223. LAG3 is a cell surface molecule expressed by activated T cells, natural killer cells, B cells and plasmacytoiddendritic cells. It binds to major histocompatibility complex (MHC) class II molecules and serves as an immune checkpoint receptor. LAG3 negatively regulates cellular proliferation, activation and homeostasisof T cells, and plays a role in Treg suppressive function. LAG3 also helps maintain CD8+ T cells in atolerogenic state and, working with PD-1, helps maintain CD8 exhaustion during chronic viral infection. LAG3 expression was detected in tumour infiltrating lymphocytes. IHC revealed LAG3 expression was distributed on lymphocytes scattered in renal cell carcinoma, melanoma and lymphomas. They were also detected in the tumour stroma as well as in the peritumoral tissue. LAG3 is the target of various drug development programs for cancer and autoimmune disorders. In soluble form, it is also being developed as a cancer drug in its own right.
Host	Mouse
Isotype	IgG2b, kappa
Species	Human

Clone No	IHC103

Buffer	Tris Buffer pH7.6 with BSA, and sodium azide as preservative
Storage	-20 degrees Celsius

Applications	WB, IHC, ELISA
Dilution	1:200

Product Manual	LAG3 Datasheet MSDS

GeneAbﾙ LAG3 [IHC103] on Tonsil

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SKU	Supplier No.	Size	Your price	Quantity
BHA14800042	IHC103-7	7ml RTU Predilute	$230		Add to Cart
BHA14800042	IHC103-7	100ul Concentrate	$100		Add to Cart
BHA14800042	IHC103-7	1ml Concentrate	$455		Add to Cart

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