KNC3Kv3.3 is a member of the Shaw type family of voltage-gated K+ channels that includes four members (Kv3.1-3.4). Kv3 subfamily members inactivate very rapidly and therefore are thought to play a role in the repolarization of action potentials and to facilitate repetitive high frequency firing. Kv3.3 is mostly localized in the brain, although it has been observed in vascular smooth muscle cells and eye epithelium. In the brain its expression pattern largely overlaps that of the Kv3.1 channel suggesting that they may form functional heteromers. Indeed, mouse knockouts of both Kv3.1 and Kv3.3, but not either channel alone, display severe motor defects.
Formulation
Liquid
Host
Rabbit(Rb)
Guarantee
abm guarantees that all our Anti-Kv3.3 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Immunogen
Peptide KSPITPGSRGRYSRDRAC corresponding toresidues 701-718 of rat Kv3.3 (Accession number Q01956).
Quantity
50μl
Recommended Dilution
Western Blotting: Rat brain membrane (1:200).Immunohistochemistry: Rat brain sections.
Shipping Condition
Ice Packs
Species Reactivity
Rat
Specificity
Recognizes only splice variant Kv3.3
Gene Name
K v3-3
Clone No
Polyclonal
Concentration
1µg/ul
Purity
Affinity purified on immobilized antigen.
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.