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Home / Antibodies

Anti-Kv3.1b Antibody

SKU : BHA10922695

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y059822
Categories	Primary Antibodies
Clonality	polyclonal
Description	Kcnc1Kv3.1 is a member of the voltage-gated K+ channel superfamily. Together with the related proteins Kv3.2, Kv3.3 and Kv3.4 they constitute the Shaw type subfamily family.1As with all Kv channels, Kv3.1 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. The functional Kv channel is a tetramer that can either be a homomer or a heteromer of Kv3 subunits.Kv3 subfamily members inactivate very rapidly and therefore are thought to play a role in the repolarization of action potentials and to facilitate repetitive high frequency firing.3Kv3.1 is highly expressed in the brain but has been also detected in peripheral organs such as lung skeletal muscle and testis.Kv3.1 and Kv3.2 are highly enriched in neurons that fire at high frequencies, such as fast spiking interneurons of the cortex and hippocampus and neurons in the globus pallidus. Their unusually rapid activation and deactivation rates allow channels containing Kv3.1 and Kv3.2 subunits to repolarize action potentials quickly thus minimizing the rate of recovery of sodium channel inactivation.3Lack of Kv3.1 channel subunits is mainly responsible for constitutively increased locomotor activity and sleep loss.
Formulation	Liquid
Host	Rabbit(Rb)
Guarantee	abm guarantees that all our Anti-Kv3.1b Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Immunogen	peptide CKESPVIAKYMPTEAVRVT, corresponding to residues 567-585 of rat Kv3.1b (Accession P25122).
Quantity	50μl
Recommended Dilution	Western Blotting: Rat brain membranes (1:200)Immunohistochemistry: Rat brain sections (see also 5,7).Immunoprecipitation.2,3
Shipping Condition	Ice Packs
Species Reactivity	Mouse ; Rat
Specificity	dog - identical.

Gene Name	K v3-1b
Clone No	Polyclonal

Concentration	1µg/ul
Purity	Affinity purified on immobilized peptide.
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Storage Condition	-20C

Description	IHC ; IP ; WB

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SKU	Supplier No.	Size	Your price	Quantity
BHA10922695	Y059822	50 ul	$1335		Add to Cart

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