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Home / Primary Antibodies / Polyclonal Antibodies

Anti-KCNS1 (KV9.1) (extracellular) Antibody

SKU : BHA21301033

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Alomone Labs

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Mfr.No.	APC-131, APC-131-CF_0.2 ml, APC-131_0.2 ml, APC-131_25 mcl, APC-131_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	K+ channels are transmembrane proteins expressed in many excitable and non-excitable cells. Functional entities are formed by the tetrameric assembly of alpha subunits which could be done in a homomeric or heteromeric fashion. In addition, the association of beta subunits is also required for the proper function of K+channels. Various splice variants are also expressed, thereby complicating the picture1,2.K+ channels belonging to the KV9 subfamily resemble the delayed-rectifier class of K+ channel a subunits. These channels include six transmembrane domains, an ion selective pore, a leucine zipper and positively charged amino acids in S4 the voltage sensor domain. Interestingly, both KV9.1 and KV9.3 channels are electrically silent delayed rectifying K+ channels. However, they are responsible for modifying the activity of other K+ channels such as that of KV2.1, yielding currents different from those of KV2.1 on its own1.KV9.1 is mainly expressed in the brain, human lens epithelial cells, kidney, prostate and testis. That of KV9.3 is more generalized and ubiquitous1.Interestingly, a polymorphism in the gene encoding for KV9.1 was identified and associated with high risks of suffering from neuropathic pain3. Evidently, additional work needs to be done to evaluate and decipher the role of KV9.1 (if at all) in chronic pain states.
Clonality	Polyclonal
Description	Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of the rat KV9.1 channel. Anti-KCNS1 (KV9.1) (extracellular) Antibody (#APC-131) can be used for western blot analysis. It has been designed to recognize KV9.1 from human mouse and rat samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	1st extracellular loop
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Potassium voltage-gated channel subfamily S member 1
UNSPSC Code	41116161
Note	Homology: Mouse, human - 12/13 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PC131 Specifictiy: KCNS1 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	O88758
Gene Id	117023
Target	Potassium voltage-gated channel subfamily S member 1
Sequence	(C)EDVRDDPVLRRLE, corresponding to amino acid residues 233-245 of rat KCNS1

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	WB
Dilution	Contact Alomone for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21301033-1	APC-131-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21301033-2	APC-131_0.2 ml	0.2 ml	$795		Add to Cart
BHA21301033-3	APC-131_25 mcl	25 mcl	$597		Add to Cart
BHA21301033-4	APC-131_50 mcl	50 mcl	$697		Add to Cart

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