JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies / Polyclonal Antibodies

Anti-KCNK12 (THIK-2) (extracellular) Antibody

SKU : BHA21301062

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	APC-169, APC-169-CF_0.2 ml, APC-169_0.2 ml, APC-169_25 mcl, APC-169_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	Potassium channels form the largest ion channel family with over 70 genes identified in humans. 2-pore domain channels (K2P) are believed to be responsible for background or leak K+ currents and they are widely expressed in the nervous system. They are involved in resting potential control and firing pattern of excitable cells1. The K2P channel family is comprised of at least 16 members.The KCNK12 channel (THIK-2, K2P12.1) has two pore domains (M1 and P1) and a long M1-P1 linker. It has a long cytosolic C terminus and a very unusual N-terminal domain containing many cysteine, proline and arginine residues. This N-terminal domain cannot be found in the similar THIK-1 channel and is highly conserved in mammals.Until recently, the THIK-2 channel was considered to be a "silent" channel and could not be functionally expressed in mammalian and non-mammalian cell lines. When removing the N-terminal both THIK-1 and THIK-2 channels exhibit similar current-voltage relations. In addition, both channels have 64% identical amino-acids in humans and 59% in rats. Only a small fraction of THIK-2 channel is localized to the cell membrane surface and this can be increased by deleting the original retention/retrieval signal RRR in its N-terminus.The THIK-2 channel is highly expressed in the cortex, cerebellum hippocampus, thalamus, inferior colliculi of the midbrain and the olfactory bulb. It is also expressed in non-neuronal tissues such as the lungs, liver, kidney and spleen2.
Clonality	Polyclonal
Description	Anti-KCNK12 (THIK-2) (extracellular) Antibody (#APC-169) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize KCNK12 from rat and mouse and human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	1st extracellular loop
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Potassium channel subfamily K member 12, Tandem pore domain halothane-inhibited K+ channel 2, K2P12.1
UNSPSC Code	41116161
Note	Homology: Mouse, human - identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PC169 Specifictiy: KCNK12 Is Toxin: No KO-Validated: yes Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	Q9ERS1
Gene Id	64119
Target	Potassium channel subfamily K member 12, Tandem pore domain halothane-inhibited K+ channel 2, K2P12.1
Sequence	(C)ESPGEAEARARWG, corresponding to amino acid residues 61-73 of rat KCNK12

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IF, IHC, WB
Dilution	1:400

Product Manual	SDS

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21301062-1	APC-169-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21301062-2	APC-169_0.2 ml	0.2 ml	$795		Add to Cart
BHA21301062-3	APC-169_25 mcl	25 mcl	$597		Add to Cart
BHA21301062-4	APC-169_50 mcl	50 mcl	$697		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.