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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Integrin alpha 3/ITGA3 Antibody Picoband®

SKU : BHA21001925

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Mfr.No.	A02902, A02902-10ug, A02902-Biotin, A02902-Cy3, A02902-Dylight488, A02902-Dylight550, A02902-Dylight594, A02902-FITC, A02902-HRP, A02902-APC, A02902-PE, A02902-iFluor647, A02902-carrier-free
Alternative Names	integrin subunit alpha 3
Background	ITGA3 (INTEGRIN, ALPHA-3), also called CD49C, VLA3 or GAPB3, is a protein that in humans is encoded by the ITGA3 gene. It is an integrin alpha subunit which is also a member of the family of cell surface adhesion molecules. This gene is mapped to chromosome 17 and its exact cytogenetic location is 17q21.33. ITGA3 makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis together with beta-1 subunit.A functional link between DAB1 phosphorylation and ITGA3 signaling drives the timely detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increased the infectivity of virus for Chinese hamster ovary cells. ITGA3 also contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and the 7 N-terminal repeating units characteristic of ITGAs. Recombinant ITGA3 is expressed as a 150-kD protein as the same size as the native protein by the weste blot analysis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Integrin alpha 3/ITGA3 Antibody Picoband® catalog # A02902. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may p
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Integrin alpha 3, which shares 91.2% amino acid (aa) sequence identity with both mouse and rat Integrin alpha 3.
Isotype	Rabbit IgG
Molecular Weight	130 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Integrin alpha-3; CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD49c; Integrin alpha-3 heavy chain; Integrin alpha-3 light chain; ITGA3; MSK18
Tissue Specificity	Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P26006
Gene Id	3675
Gene Name	ITGA3
Subcellular Location	Cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Akula, S. M., Pramod, N. P., Wang, F.-Z., Chandran, B. Integrin alpha-3/beta-1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells. Cell 108: 407-419, 2002. <br /><br />2. Dulabon, L., Olson, E. C., Taglienti, M. G., Eisenhuth, S., McGrath, B., Walsh, C. A., Kreidberg, J. A., Anton, E. S. Reelin binds alpha-3-beta-1 integrin and inhibits neuronal migration. Neuron 27: 33-44, 2000. <br /><br />3. Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (Oct 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen".

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001925-1	A02902	100 ug	-	$370		Add to Cart
BHA21001925-2	A02902-10ug	10 ug	Sample	$99		Add to Cart
BHA21001925-3	A02902-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001925-4	A02902-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001925-5	A02902-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001925-6	A02902-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001925-7	A02902-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001925-8	A02902-FITC	100 ug	FITC	$570		Add to Cart
BHA21001925-9	A02902-HRP	100 ug	HRP	$570		Add to Cart
BHA21001925-10	A02902-APC	100 ug	APC	$670		Add to Cart
BHA21001925-11	A02902-PE	100 ug	PE	$670		Add to Cart
BHA21001925-12	A02902-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001925-13	A02902-carrier-free	100 ug	carrier-free	$370		Add to Cart

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