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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IL2 Receptor beta/p75/IL2RB Antibody Picoband®

SKU : BHA21003060

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Mfr.No.	A03401-3, A03401-3-10ug, A03401-3-Biotin, A03401-3-Cy3, A03401-3-Dylight488, A03401-3-Dylight550, A03401-3-Dylight594, A03401-3-FITC, A03401-3-HRP, A03401-3-APC, A03401-3-PE, A03401-3-iFluor647, A03401-3-carrier-free
Alternative Names	Interleukin-12 receptor subunit beta-1
Background	The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alteative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alteate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IL2RB Antibody Picoband® catalog # A03401-3. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 r
Host	Rabbit
Immunogen Region	E.coli-derived human IL2 Receptor beta/p75/IL2RB recombinant protein (Position: R268-V551).
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Interleukin-12 receptor subunit beta-1;IL-12 receptor subunit beta-1;IL-12R subunit beta-1;IL-12R-beta-1;IL-12RB1;IL-12 receptor beta component;CD212;IL12RB1;IL12R, IL12RB;
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.005mg NaN3.

Uniprot	P14784
Gene Id	3560
Gene Name	IL2RB
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1.Campbell, H. D., Webb, G. C., Kono, T., Taniguchi, T., Ford, J. H., Young, I. G. Assignment of the interleukin-2 receptor beta chain gene (Il-2rb) to band E on mouse chromosome 15. Genomics 12: 179-180, 1992.<br /><br />2.Corrigall, V. M., Arastu, M., Khan, S., Shah, C., Fife, M., Smeets, T., Tak, P.-P., Panayi, G. S. Functional IL-2 receptor beta (CD122) and gamma (CD132) chains are expressed by fibroblast-like synoviocytes: activation by IL-2 stimulates monocyte chemoattractant protein-1 production. J. Immun. 166: 4141-4147, 2001.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003060-1	A03401-3	-	100 ug	$370		Add to Cart
BHA21003060-2	A03401-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003060-3	A03401-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003060-4	A03401-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003060-5	A03401-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003060-6	A03401-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003060-7	A03401-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003060-8	A03401-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003060-9	A03401-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003060-10	A03401-3-APC	APC	100 ug	$670		Add to Cart
BHA21003060-11	A03401-3-PE	PE	100 ug	$670		Add to Cart
BHA21003060-12	A03401-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003060-13	A03401-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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