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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Human NFATC4 DyLight® 550 conjugated Antibody

SKU : BHA21002022

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Mfr.No.	A02599-Dyl550
Alternative Names	nuclear factor of activated T-cells 4
Background	Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene. This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Human NFATC4 DyLight® 550 conjugated Antibody catalog # A02599-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Function	Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional act
Host	Rabbit
Immunogen Region	E. coli-derived human NFATC4 recombinant protein (Position: Q413-D522).
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human
Specificity	No cross reactivity with other proteins.
Synonyms	Nuclear factor of activated T-cells, cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3; NFATC4; NFAT3
Tissue Specificity	Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
Note	Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Uniprot	Q14934
Gene Id	4776
Gene Name	NFATC4
Subcellular Location	Cytoplasm

Conjugates	DyLight 550

Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Form	Liquid
Storage	At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications	Flow Cytometry
Description	Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells

Reference	1. Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 46172.<br /><br />2. Yang T, Davis RJ, Chow CW (Oct 2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation". The Joual of Biological Chemistry. 276 (43): 3956976.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002022-1	A02599-Dyl550	-	100 ug	$515		Add to Cart

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