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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Human CD18 DyLight® 550 conjugated ITGB2 Antibody(monoclonal, 1A3/2A10)

SKU : BHA21002028

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Mfr.No.	M00458-Dyl550
Alternative Names	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Background	ITGB2 (INTEGRIN, BETA-2), also known as CD18, is a protein that in humans is encoded by the ITGB2 gene. ITGB2 is an integrin protein that belongs to the class of cell membrane glycoproteins. The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated CD18. The ITGB2 gene is mapped to 21q22.3. The expression of CD18 is increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21. In humans lack of ITGB2 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. Although ITGB2 is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, it could not be activated via the 'inside-out' signaling pathways.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Human CD18 DyLight® 550 conjugated ITGB2 Antibody (monoclonal, 1A3/2A10) catalog # M00458-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Function	Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence
Host	Mouse
Immunogen Region	E.coli-derived human CD18 recombinant protein (Position: Q404-S769). Human CD18 shares 76% amino acid (aa) sequence identity with mouse CD18.
Isotype	Mouse IgG1
Molecular Weight	39 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD18; ITGB2; CD18; MFI7
Tissue Specificity	Leukocytes.
Note	Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Uniprot	P05107
Gene Id	3689
Gene Name	ITGB2
Clone No	Clone: 1A3/2A10
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	DyLight 550

Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Form	Liquid
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications	Flow Cytometry
Description	Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells

Reference	1. Abramson, J. S., Mills, E. L., Sawyer, M. K., Regelmann, W. R., Nelson, J. D., Quie, P. G. Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis. J. Pediat. 99: 887-894, 1981.<br /><br />2. Akao, Y., Utsumi, K. R., Naito, K., Ueda, R., Takahashi, T., Yamada, K. Chromosomal assignments of genes coding for human leukocyte common antigen, T-200, and lymphocyte function-associated antigen 1, LFA-1 beta subunit. Somat. Cell Molec. Genet. 13: 273-278, 1987.<br /><br />3. "Entrez Gene: ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)".

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002028-1	M00458-Dyl550	-	100 ug	$515		Add to Cart

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