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Home / Primary Antibodies

Anti-Human Bcl-2 Antibody

SKU : BHA10921716

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y050392
Categories	Primary Antibodies
Clonality	polyclonal
Description	Bcl-2 is a human proto-oncogene located chromosome 18. Its product is an integralmembrane protein (also called Bcl-2) located in the membranes of the endoplasmic reticulum (ER), nuclearenvelope, and in the outer membranes of the mitochondria. The gene was discovered as the translocated locusin a B-cell leukemia (hence the name). This translocation is also found in some B-cell lymphomas. In thecancerous B cells, the portion of chromosome 18 containing the BCL-2 locus has undergone a reciprocaltranslocation with the portion of chromosome 14 containing the antibody heavy chain locus. This t(14;18)translocation places the BCL-2 gene close to the heavy chain gene enhancer. This enhancer is very active in Bcells and therefore results in high levels of Bcl-2 expression in these cells. High levels of the Bcl-2 protein protectthe cells from early death by apoptosis. The Bcl-2 protein suppresses apoptosis by preventing the activation ofthe caspases that carry out the process. It is conceived that introduction of the Bcl-2 gene into the cells of injuredtissue will reduce cell death and improve the clinical outcome of the injury
Formulation	Liquid
Host	Rabbit(Rb)
Guarantee	abm guarantees that all our Anti-Human Bcl-2 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Immunogen	This purified IgG antibody was prepared from rabbit serum by repeated immunizations with asynthetic peptide corresponding to amino acids 62-76 (RDPVARTSPLQTPAA) of human Bcl-2.
Isotype	IgG
Quantity	100 μg
Recommended Dilution	This purified IgG antibody against Human Bcl-2 has been tested for use inimmunofluorescence microscopy and immunoblotting. The antibody recognizes a 27 kDa band corresponding tohuman bcl-2. Anti-Bcl-2 shows perinuclear staining of Bcl-2. Reactivity in other immunoassays is unknown.
Shipping Condition	Ice Packs
Species Reactivity	Human
Specificity	This purified IgG antibody was prepared from monospecific rabbit antiserum by Protein Achormatography. The antibody is directed against human Bcl-2 and is useful in determining its presence invarious assays.

Gene Name	Human Bcl-2
Clone No	Polyclonal

Concentration	1µg/ul
Purity	Purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Storage Condition	-20C

Description	IF ; WB

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SKU	Supplier No.	Size	Your price	Quantity
BHA10921716	Y050392	100 ug	$1162.50		Add to Cart

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