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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Hsp105/HSPH1 Antibody Picoband®

SKU : BHA21001781

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Mfr.No.	A04168, A04168-10ug, A04168-Biotin, A04168-Cy3, A04168-Dylight488, A04168-Dylight550, A04168-Dylight594, A04168-FITC, A04168-HRP, A04168-APC, A04168-PE, A04168-iFluor647, A04168-carrier-free
Alternative Names	heat shock 105kDa/110kDa protein 1
Background	HSP105 (HEAT-SHOCK 105/110-KD PROTEIN 1), also called HSPH1 or HSP110, is a protein that in humans is encoded by the HSPH1 gene. Immunohistochemical analysis localizes HSP105 mainly in the cytoplasm. Database analysis indicates that both HSP105 isoforms are highly conserved during evolution. By analysis of radiation hybrids and human/rodent hybrid cell lines, the HSPH1 gene is mapped to chromosome 13. Both HSP105-alpha and HSP105-beta are upregulated in HeLa cells exposed to heat shock. HSP105-alpha, but not HSP105-beta, is also upregulate in response to other cell stresses. Following heat shock, HSP105 relocalizes from a cytoplasmic to perinuclear position. Besides, HSP110 may thus constitute a major determinant for both prognosis and treatment response in colorectal cancer.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Hsp105/HSPH1 Antibody Picoband® catalog # A04168. Tested in ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells
Host	Rabbit
Immunogen Region	E. coli-derived human Hsp105 recombinant protein (Position: Y653-D858).
Isotype	Rabbit IgG
Molecular Weight	105 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Heat shock protein 105 kDa; Antigen NY-CO-25; Heat shock 110 kDa protein; HSPH1; HSP105; HSP110; KIAA0201
Tissue Specificity	Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q92598
Gene Id	10808
Gene Name	HSPH1
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Ishihara, K., Yasuda, K., Hatayama, T. Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105. Biochim. Biophys. Acta 1444: 138-142, 1999. <br /><br />2. Dorard, C., de Thonel, A., Collura, A., Marisa, L., Svrcek, M., Lagrange, A., Jego, G., Wanherdrick, K., Joly, A. L., Buhard, O., Gobbo, J., Penard-Lacronique, V., and 16 others. Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis. Nature Med. 17: 1283-1289, 2011.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001781-1	A04168	100 ug	-	$370		Add to Cart
BHA21001781-2	A04168-10ug	10 ug	Sample	$99		Add to Cart
BHA21001781-3	A04168-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001781-4	A04168-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001781-5	A04168-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001781-6	A04168-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001781-7	A04168-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001781-8	A04168-FITC	100 ug	FITC	$570		Add to Cart
BHA21001781-9	A04168-HRP	100 ug	HRP	$570		Add to Cart
BHA21001781-10	A04168-APC	100 ug	APC	$670		Add to Cart
BHA21001781-11	A04168-PE	100 ug	PE	$670		Add to Cart
BHA21001781-12	A04168-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001781-13	A04168-carrier-free	100 ug	carrier-free	$370		Add to Cart

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