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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HSD11B2 Antibody Picoband®

SKU : BHA21000651

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Mfr.No.	RP1094, RP1094-10ug, RP1094-Biotin, RP1094-Cy3, RP1094-Dylight488, RP1094-Dylight550, RP1094-Dylight594, RP1094-FITC, RP1094-HRP, RP1094-APC, RP1094-PE, RP1094-iFluor647, RP1094-carrier-free
Alternative Names	Corticosteroid 11-beta-dehydrogenase isozyme 2
Background	Corticosteroid 11-beta-dehydrogenase isozyme 2, also known as 11-beta-hydroxysteroid dehydrogenase 2, is an enzyme that in humans is encoded by the HSD11B2 gene. There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-HSD11B2 Antibody catalog # RP1094. Tested in IF, IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human HSD11B2, different from the related mouse sequence by five amino acids, and from the related rat sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	43 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Corticosteroid 11-beta-dehydrogenase isozyme 2;1.1.1.-;11-beta-hydroxysteroid dehydrogenase type 2;11-DH2;11-beta-HSD2;11-beta-hydroxysteroid dehydrogenase type II;11-HSD type II;11-beta-HSD type II;NAD-dependent 11-beta-hydroxysteroid dehydrogenase;11-beta-HSD;Short chain dehydrogenase/reductase family 9C member 3;HSD11B2;HSD11K , SDR9C3;
Tissue Specificity	Expressed in kidney, pancreas, prostate, ovary, small intestine and colon. At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis (PubMed:8530071). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P80365
Gene Id	3291
Gene Name	HSD11B2
Subcellular Location	Microsome . Endoplasmic reticulum .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, IHC-F, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunohistochemistry(Frozen Section), 2-5 ug/ml, Human, Mouse, Rat Immunofluorescence, 5 ug/ml, Human

Reference	1. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS (November 1994). "Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme". Mol. Cell. Endocrinol. 105 (2): R117. 2. Brown RW, Chapman KE, Kotelevtsev Y, Yau JL, Lindsay RS, Brett L, Leckie C, Murad P, Lyons V, Mullins JJ, Edwards CR, Seckl JR (February 1996). "Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2". Biochem. J. 313 ( Pt 3) (Pt 3): 100717.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000651-1	RP1094	100 ug	-	$370		Add to Cart
BHA21000651-2	RP1094-10ug	10 ug	Sample	$99		Add to Cart
BHA21000651-3	RP1094-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000651-4	RP1094-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000651-5	RP1094-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000651-6	RP1094-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000651-7	RP1094-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000651-8	RP1094-FITC	100 ug	FITC	$570		Add to Cart
BHA21000651-9	RP1094-HRP	100 ug	HRP	$570		Add to Cart
BHA21000651-10	RP1094-APC	100 ug	APC	$670		Add to Cart
BHA21000651-11	RP1094-PE	100 ug	PE	$670		Add to Cart
BHA21000651-12	RP1094-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000651-13	RP1094-carrier-free	100 ug	carrier-free	$370		Add to Cart

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