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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HMGN2 Antibody Picoband®

SKU : BHA21001919

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Mfr.No.	A04839-2, A04839-2-10ug, A04839-2-Biotin, A04839-2-Cy3, A04839-2-Dylight488, A04839-2-Dylight550, A04839-2-Dylight594, A04839-2-FITC, A04839-2-HRP, A04839-2-APC, A04839-2-PE, A04839-2-iFluor647, A04839-2-carrier-free
Alternative Names	high mobility group nucleosomal binding domain 2
Background	Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene. It is mapped to 1p36.11. The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HMGN2 Antibody Picoband® catalog # A04839-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human HMGN2, which shares 94.3% and 88.6% amino acid (aa) sequence identity with mouse and rat HMGN2, respectively.
Isotype	Rabbit IgG
Molecular Weight	18 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	NACHT, LRR and PYD domains-containing protein 2; Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; NLRP2; NALP2; NBS1; PAN1; PYPAF2
Tissue Specificity	Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P05204
Gene Id	3151
Gene Name	HMGN2
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br>Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. Porkka, K., Laakkonen, P., Hoffman, J. A., Beasconi, M., Ruoslahti, E. A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo. Proc. Nat. Acad. Sci. 99: 7444-7449, 2002. <br /><br />2. West, K. L., Ito, Y., Birger, Y., Postnikov, Y., Shirakawa, H., Bustin, M.HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression patte, expand the cellular repertoire of nucleosome-binding proteins. J. Biol. Chem. 276: 25959-25969, 2001.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001919-1	A04839-2	100 ug	-	$370		Add to Cart
BHA21001919-2	A04839-2-10ug	10 ug	Sample	$99		Add to Cart
BHA21001919-3	A04839-2-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001919-4	A04839-2-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001919-5	A04839-2-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001919-6	A04839-2-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001919-7	A04839-2-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001919-8	A04839-2-FITC	100 ug	FITC	$570		Add to Cart
BHA21001919-9	A04839-2-HRP	100 ug	HRP	$570		Add to Cart
BHA21001919-10	A04839-2-APC	100 ug	APC	$670		Add to Cart
BHA21001919-11	A04839-2-PE	100 ug	PE	$670		Add to Cart
BHA21001919-12	A04839-2-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001919-13	A04839-2-carrier-free	100 ug	carrier-free	$370		Add to Cart

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