HIRA is the human homologue of two cell cycle-regulated repressors of histone gene expression in Saccharomyces cerevisiae, Hir1p and Hir2p. In yeast, Hir1p and Hir2p control histone gene expression through the cell cycle. In human cells, HIRA contributes to formation of transcriptionally-repressive heterochromatin in senescent cells and also has roles in transcription-coupled chromatin assembly.
Specificity: Reacts with human HIRA.Relevance: HIRA is the human homologue of two cell cycle-regulated repressors of histone gene expression.
Format
Liquid
Purity
Purified ascites.
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition
-20C
Applications
WB
Description
Titrate for optimal conditions for your specific application., WB