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Home / Primary Antibodies / Monoclonal Antibodies

Anti-HIF1 alpha (Hypoxia-Inducible Factor 1-alpha) Antibody BHA10201764

SKU : BHA10201764

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NeoBiotechnologies, Inc.

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Mfr.No.	3091-MSM1-P1ABX
Alternative Names	ARNT-interacting protein ; Basic-helix-loop-helix-PAS protein MOP1 ; Class E basic helix-loop-helix protein 78 (bHLHe78) ; Hypoxia inducible factor 1 alpha ; Member of PAS superfamily 1 (MOP1) ; PAS domain-containing protein 8 (PASD8)
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic, Nuclear
Chromosome Location	14q23.2
Clonality	Monoclonal
Description	HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.
Host	Mouse
Immunogen	Recombinant human HIF1 alpha protein
Isotype	IgG2b Kappa
Positive Control	Cobalt chloride treated HeLa cells. Breast or bladder carcinomas.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q16665
Uniprot	597216
Gene Id	3091

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF

Description

Optimal dilution for a specific application should be determined., FACS ; IF

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201764	3091-MSM1-P1ABX	100µg	$393.20		Add to Cart

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