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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Hamartin/TSC1 Antibody Picoband®

SKU : BHA21007237

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Mfr.No.	PA2012, PA2012-10ug, PA2012-Biotin, PA2012-Cy3, PA2012-Dylight488, PA2012-Dylight550, PA2012-Dylight594, PA2012-FITC, PA2012-HRP, PA2012-APC, PA2012-PE, PA2012-iFluor647, PA2012-carrier-free
Alternative Names	Hamartin
Background	TSC1 (Tuberous Sclerosis 1), also called HAMARTIN or TSC, is a human protein and gene. As part of a comprehensive strategy to identify the gene mutant in tuberous sclerosis-1, van Slegtenhorst et al. (1997) developed an overlapping contig of clones from the 1.4-Mb TSC1 region on chromosome 9. Benvenuto et al. (2000) showed that overexpression of the TSC1 gene in rat fibroblasts inhibits growth and causes changes in cell morphology. Van Slegtenhorst et al. (1998) showed that hamartin and tuberin associate physically in vivo, however, and that the interaction is mediated by predicted coiled-coil domains.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Hamartin/TSC1 Antibody catalog # PA2012. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Hamartin, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	160 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Hamartin;Tuberous sclerosis 1 protein;TSC1;KIAA0243, TSC;
Tissue Specificity	Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q92574
Gene Name	TSC1
Subcellular Location	Cytoplasm . Membrane ; Peripheral membrane protein . At steady state found in association with membranes.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>

Reference	1. Benvenuto, G., Li, S., Brown, S. J., Braverman, R., Vass, W. C., Cheadle, J. P., Halley, D. J. J., Sampson, J. R., Wienecke, R., DeClue, J. E. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19: 6306-6316, 2000.<br /><br />2. van Slegtenhorst, M., de Hoogt, R., Hermans, C., Nellist, M., Janssen, B., Verhoef, S., Lindhout, D., van den Ouweland, A., Halley, D., Young, J., Burley, M., Jeremiah, S., and 29 others. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277: 805-808, 1997.<br /><br />3. van Slegtenhorst, M., Nellist, M., Nagelkerken, B., Cheadle, J., Snell, R., van den Ouweland, A., Reuser, A., Sampson, J., Halley, D., van der Sluijs, P. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum. Molec. Genet. 7: 1053-1057, 1998.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007237-1	PA2012	-	100 ug	$370		Add to Cart
BHA21007237-2	PA2012-10ug	Sample	10 ug	$99		Add to Cart
BHA21007237-3	PA2012-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007237-4	PA2012-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007237-5	PA2012-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007237-6	PA2012-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007237-7	PA2012-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007237-8	PA2012-FITC	FITC	100 ug	$570		Add to Cart
BHA21007237-9	PA2012-HRP	HRP	100 ug	$570		Add to Cart
BHA21007237-10	PA2012-APC	APC	100 ug	$670		Add to Cart
BHA21007237-11	PA2012-PE	PE	100 ug	$670		Add to Cart
BHA21007237-12	PA2012-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007237-13	PA2012-carrier-free	carrier-free	100 ug	$370		Add to Cart

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