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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Hamartin/TSC1 Antibody Picoband®

SKU : BHA21005003

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Mfr.No.	A00365-2, A00365-2-10ug, A00365-2-Biotin, A00365-2-Cy3, A00365-2-Dylight488, A00365-2-Dylight550, A00365-2-Dylight594, A00365-2-FITC, A00365-2-HRP, A00365-2-APC, A00365-2-PE, A00365-2-iFluor647, A00365-2-carrier-free
Alternative Names	ETS variant 6
Background	Hamartin also known as tuberous sclerosis 1 is a protein that in humans is encoded by the TSC1 gene. It is mapped to 9q34.13. This peripheral membrane protein was implicated as a tumor suppressor. It forms a complex with TSC2 that regulates mTORC1 signaling and may be also involved in vesicular transport and docking. Hamartin and TSC2 have critical roles in neuronal polarity, and that a common pathway regulates polarization and growth in neurons and cell size in other tissues. Hamartin is a growth inhibitory protein whose biologic effect is probably dependent on its interaction with tuberin. It also can affect cell proliferation via deregulation of G1 phase. Loss or perturbation of Hamartin function leads to loss of adhesion to the cellular matrix and initiates the development of TSC hamartomas.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Hamartin/TSC1 Antibody Picoband® catalog # A00365-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with HumanThe brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
Host	Rabbit
Immunogen Region	E.coli-derived human Hamartin/TSC1 recombinant protein (Position: M1-H618).
Isotype	Rabbit IgG
Molecular Weight	160 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Transcription factor ETV6; ETS translocation variant 6; ETS-related protein Tel1; Tel; ETV6; TEL; TEL1
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q92574
Gene Id	7248
Gene Name	TSC1
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Benvenuto, G., Li, S., Brown, S. J., Braverman, R., Vass, W. C., Cheadle, J. P., Halley, D. J. J., Sampson, J. R., Wienecke, R., DeClue, J. E. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19: 6306-6316, 2000.<br /><br />2. Choi, Y.-J., Di Nardo, A., Kramvis, I., Meikle, L., Kwiatkowski, D. J., Sahin, M., He, X. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 22: 2485-2495, 2008. <br /><br />3. Tapon, N., Ito, N., Dickson, B. J., Treisman, J. E., Hariharan, I. K. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105: 345-355, 2001.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005003-1	A00365-2	-	100 ug	$370		Add to Cart
BHA21005003-2	A00365-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21005003-3	A00365-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005003-4	A00365-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005003-5	A00365-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005003-6	A00365-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005003-7	A00365-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005003-8	A00365-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21005003-9	A00365-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21005003-10	A00365-2-APC	APC	100 ug	$670		Add to Cart
BHA21005003-11	A00365-2-PE	PE	100 ug	$670		Add to Cart
BHA21005003-12	A00365-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005003-13	A00365-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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