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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Growth hormone receptor/GHR Picoband® Antibody

SKU : BHA21002538

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Mfr.No.	A00698, A00698-10ug, A00698-Biotin, A00698-Cy3, A00698-Dylight488, A00698-Dylight550, A00698-Dylight594, A00698-FITC, A00698-HRP, A00698-APC, A00698-PE, A00698-iFluor647, A00698-carrier-free
Alternative Names	growth hormone receptor
Background	Growth hormone receptor is a protein that in humans is encoded by the GHR gene. It is mapped to 5p13.1-p12. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alteatively spliced transcript variants have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Growth hormone receptor/GHR Picoband® Antibody catalog # A00698. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH
Host	Rabbit
Immunogen Region	E.coli-derived human Growth hormone receptor/GHR recombinant protein (Position: F19-P638).
Isotype	Rabbit IgG
Molecular Weight	80 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Growth hormone receptor; GH receptor; Somatotropin receptor; Growth hormone-binding protein; Growth hormone-binding protein;
Tissue Specificity	Expressed in lung and placenta.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P10912
Gene Id	2690
Gene Name	GHR
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Horan, M., Newsway, V., Yasmin, (NI), Lewis, M. D., Easter, T. E., Rees, D. A., Mahto, A., Millar, D. S., Procter, A. M., Scanlon, M. F., Wilkinson, I. B., Hall, I. P., Wheatley, A., Blakey, J., Bath, P. M. W., Cockcroft, J. R., Krawczak, M., Cooper, D. N. Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke. Hum. Genet. 119: 527-540, 2006.<br /><br />2. Pantel, J., Grulich-Henn, J., Bettendorf, M., Strasburger, C. J., Heinrich, U., Amselem, S. Heterozygous nonsense mutation in exon 3 of the growth hormone receptor (GHR) in severe GH insensitivity (Laron syndrome) and the issue of the origin and function of the GHRd3 isoform. J. Clin. Endocr. Metab. 88: 1705-1710, 2003.<br /><br />3. Tiulpakov, A., Rubstov, P., Dedov, I., Peterkova, V., Bezlepkina, O., Chrousos, G. P., Hochberg, Z. A novel C-terminal growth hormone receptor (GHR) mutation results in impaired GHR-STAT5 but normal STAT-3 signaling. J. Clin. Endocr. Metab. 90: 542-547, 2005.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002538-1	A00698	-	100 ug	$370		Add to Cart
BHA21002538-2	A00698-10ug	Sample	10 ug	$99		Add to Cart
BHA21002538-3	A00698-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002538-4	A00698-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002538-5	A00698-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002538-6	A00698-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002538-7	A00698-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002538-8	A00698-FITC	FITC	100 ug	$570		Add to Cart
BHA21002538-9	A00698-HRP	HRP	100 ug	$570		Add to Cart
BHA21002538-10	A00698-APC	APC	100 ug	$670		Add to Cart
BHA21002538-11	A00698-PE	PE	100 ug	$670		Add to Cart
BHA21002538-12	A00698-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002538-13	A00698-carrier-free	carrier-free	100 ug	$370		Add to Cart

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