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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GRB10 Antibody Picoband®

SKU : BHA21002834

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Mfr.No.	A01663-2, A01663-2-10ug, A01663-2-Biotin, A01663-2-Cy3, A01663-2-Dylight488, A01663-2-Dylight550, A01663-2-Dylight594, A01663-2-FITC, A01663-2-HRP, A01663-2-APC, A01663-2-PE, A01663-2-iFluor647, A01663-2-carrier-free
Alternative Names	deoxycytidine kinase
Background	GRB10, Growth factor receptor-bound protein 10, also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alteatively spliced transcript variants encoding different isoforms have been identified.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-GRB10 Antibody Picoband® catalog # A01663-2. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essentia
Host	Rabbit
Immunogen Region	E.coli-derived human GRB10 recombinant protein (Position: M1-K251).
Isotype	Rabbit IgG
Molecular Weight	76 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Deoxycytidine kinase; dCK; DCK;
Tissue Specificity	Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q13322
Gene Id	2887
Gene Name	GRB10
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Monkey, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Rat<br> Flow Cytometry(Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Aaud, P., Monk, D., Hitchins, M., Gordon, E., Dean, W., Beechey, C. V., Peters, J., Craigen, W., Preece, M., Stanier, P., Moore, G. E., Kelsey, G.Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark.Hum. Molec. Genet. 12: 1005-1019, 2003.<br /><br />2. Charalambous, M., Smith, F. M., Bennett, W. R., Crew, T. E., Mackenzie, F., Ward, A.Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.Proc. Nat. Acad. Sci. 100: 8292-8297, 2003.<br /><br />3. Frantz, J. D., Giorgetti-Peraldi, S., Ottinger, E. A., Shoelson, S. E.Human GRB-IR-beta/GRB10: splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.J. Biol. Chem. 272: 2659-2667, 1997.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002834-1	A01663-2	-	100 ug	$370		Add to Cart
BHA21002834-2	A01663-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002834-3	A01663-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002834-4	A01663-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002834-5	A01663-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002834-6	A01663-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002834-7	A01663-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002834-8	A01663-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002834-9	A01663-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002834-10	A01663-2-APC	APC	100 ug	$670		Add to Cart
BHA21002834-11	A01663-2-PE	PE	100 ug	$670		Add to Cart
BHA21002834-12	A01663-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002834-13	A01663-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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