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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GJC2 Antibody Picoband®

SKU : BHA21000606

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Mfr.No.	PB9706, PB9706-10ug, PB9706-Biotin, PB9706-Cy3, PB9706-Dylight488, PB9706-Dylight550, PB9706-Dylight594, PB9706-FITC, PB9706-HRP, PB9706-APC, PB9706-PE, PB9706-iFluor647, PB9706-carrier-free
Alternative Names	Gap junction gamma-2 protein
Background	Gap junction gamma-2 (GJC2), also known as connexin-46.6 (Cx46.6) and connexin-47 (Cx47) and gap junction alpha-12 (GJA12), is a protein that in humans is encoded by the GJC2 gene. It is mapped to 1q42.13. This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-GJC2 Antibody Picoband® catalog # PB9706. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous system
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human GJC2, different from the related mouse and rat sequences by five amino acids.
Isotype	Rabbit IgG
Molecular Weight	47 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Gap junction gamma-2 protein;Connexin-46.6;Cx46.6;Connexin-47;Cx47;Gap junction alpha-12 protein;GJC2;GJA12;
Tissue Specificity	Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q5T442
Gene Id	57165
Gene Name	GJC2
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Ferrell RE, Baty CJ, Kimak MA; et al. (2010). "GJC2 missense mutations cause human lymphedema.". Am. J. Hum. Genet. 86 (6): 9438. 2. Ostergaard P, Simpson MA, Brice G; et al. (2011). "Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype.". J. Med. Genet. 48 (4): 2515. 3. Wolf NI, Cundall M, Rutland P; et al. (2007). "Frameshift mutation in GJA12 leading to nystagmus, spastic ataxia and CNS dys-/demyelination.".Neurogenetics 8 (1): 3944.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000606-1	PB9706	100 ug	-	$370		Add to Cart
BHA21000606-2	PB9706-10ug	10 ug	Sample	$99		Add to Cart
BHA21000606-3	PB9706-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000606-4	PB9706-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000606-5	PB9706-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000606-6	PB9706-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000606-7	PB9706-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000606-8	PB9706-FITC	100 ug	FITC	$570		Add to Cart
BHA21000606-9	PB9706-HRP	100 ug	HRP	$570		Add to Cart
BHA21000606-10	PB9706-APC	100 ug	APC	$670		Add to Cart
BHA21000606-11	PB9706-PE	100 ug	PE	$670		Add to Cart
BHA21000606-12	PB9706-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000606-13	PB9706-carrier-free	100 ug	carrier-free	$370		Add to Cart

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