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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GIRK3 (Kir3.3) Antibody

SKU : BHA21300967

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Alomone Labs

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Mfr.No.	APC-038, APC-038-CF_0.2 ml, APC-038_0.2 ml, APC-038_25 mcl, APC-038_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	Kir3.3 (or G-protein regulated Inward-Rectifier K+ channel, GIRK3) is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.The family's topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heterotetramers.Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis.Kir3.3 is a member of the Kir3.x subfamily that includes four members (Kir3.1- Kir3.4). The Kir3 family is characterized by the fact that the channels can be activated by neurotransmitters and other factors acting via the activation of G-protein coupled receptors. Binding of the corresponding ligand to the G-protein receptor induces the dissociation of Ga-GTP from the Gbg dimer. The latter directly binds to Kir3 and activates the channel.1,2Kir3.3 is mainly expressed in the brain, were it co-assembles with Kir3.1 or Kir3.2. The functional impact of Kir3.3 is less well understood than the other Kir3 channels. However, heteromers composed of Kir3.2 and Kir3.3 were found to be primarily responsible for the opioid-induced current and hyperpolarization observed in mouse locus ceruleus (LC) neurons.3
Clonality	Polyclonal
Description	Anti-GIRK3 (Kir3.3) Antibody (#APC-038) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize Kir3.3 from human, rat, and mouse samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Intracellular, C-terminus
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	G protein-activated inward rectifier potassium channel 3, KCNJ9
UNSPSC Code	41116161
Note	Homology: Mouse, human - identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PC038 Specifictiy: KCNJ9 Is Toxin: No KO-Validated: yes Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	Q63511
Gene Id	116560
Target	G protein-activated inward rectifier potassium channel 3, KCNJ9
Sequence	(C)RLDAHLYWSIPSRLDEKV, corresponding to residues 344-361 of rat KCNJ9

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IC, IF, IHC, WB
Dilution	1:400

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300967-1	APC-038-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300967-2	APC-038_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300967-3	APC-038_25 mcl	25 mcl	$597		Add to Cart
BHA21300967-4	APC-038_50 mcl	50 mcl	$697		Add to Cart

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