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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GABA(A) rho1 Receptor (GABRR1) (extracellular) Antibody

SKU : BHA21300357

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Alomone Labs

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Mfr.No.	AGA-006, AGA-006-CF_0.2 ml, AGA-006_0.2 ml, AGA-006_25 mcl, AGA-006_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	gamma-Aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter. It is involved in roughly 40% of the inhibitory synapses1,2.GABA acts through two receptors, GABA(A) and GABA(B). To date, nineteen different GABA(A) subunits have been identified and divided in eight subunits: alpha (1-6), beta (1-3), gamma (1-3), delta, epsilon, rho (1-3), theta and pi. For some of the subunits, alternative splicing further increases the number of existing receptor types. They all have extracellular N- and C-termini and four transmembrane domains1.Three rho subunits have been detected: GABA(A) rho1, GABA(A) rho2 and GABA(A) rho3. Like all GABA(A) receptors the rho subunits also assemble into a pentameric structure forming a Cl- channel. However, in contrast to all other GABA(A) subunits they mostly form homomeric entities. The GABA(A) rho subunits display different pharmacological characteristics and were therefore once referred to GABA(C) receptors. GABA(A) and GABA(B) respectively respond to bicuculline and baclofen, whereas rho subunits are insensitive to either drug3-7. In addition, rho subunits also display different electrophysiological properties, and are significantly more sensitive to GABA3,5,6,8.Rho subunits are highly expressed in the retina and it was believed that they are only expressed in that area. They are however, also expressed in central and peripheral nervous systems, as well as in the gastrointestinal and cardiovascular systems1.
Clonality	Polyclonal
Description	Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat GABA(A) rho-1 subunit. Anti-GABA(A) rho1 Receptor (GABRR1) (extracellular) Antibody (#AGA-006) can be used in western blot analysis and was designed to recognize GABA(A) rho1 from human, rat and mouse samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Extracellular, N-terminus
Isotype	Rabbit IgG
Reactivity	Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	gamma-Aminobutyric acid receptor subunit rho1, GABA(C) rho1
UNSPSC Code	41116161
Note	Homology: Mouse, human - 12/13 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-GA006 Specifictiy: GABRR1 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P50572
Gene Id	29694
Target	gamma-Aminobutyric acid receptor subunit rho1, GABA(C) rho1
Sequence	(C)ESTVHWPGREVHE, corresponding to amino acid residues 23-35 of rat GABRR1

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	WB
Dilution	Immunohistochemistry paraffin embedded sections ihc: Contact Biohippo for information Western blot wb: 1:200

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300357-1	AGA-006-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300357-2	AGA-006_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300357-3	AGA-006_25 mcl	25 mcl	$597		Add to Cart
BHA21300357-4	AGA-006_50 mcl	50 mcl	$697		Add to Cart

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